Propofol and Thiopentone for total intravenous anaesthesia: A comparative study.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
Background: To evaluate the safety and efficacy of propofol, to measure recovery times and to compare the return of psychomotor and cognitive function with thiopentone. Desigen of the study was a prospective randomized study. Method:The study population consisted of 60 patients, ASA physical status I and II aged between 18 to 70 years, scheduled for elective operative procedures of anticipated intermediate duration (15-60 mintues) at H.N.B. BASE TECHING HOSPITAL SRINAGAR UTTARAKHAND i.e laparoscopy , Arthroscopy were studied. Patients were randomly allocated into two groups. Propofol n=30 and thiopentone n=30 Anaesthesia was induced and maintained by either propofol (2.0-2.5mg. kg-1 followed by a continuous infusion .1-.2 mg. kg1. min-1 ) or thiopentone (4.0_5.0 mg.kg-1 and infusion rate 0.16_0.32 mg.kg-1.min-1), titrated to patients response. Succinylcholine was administered to facilitate tracheal intubation and maintain neuro muscular blockade. Results: Induction of anesthesia was slightly longer with propofol than thiopentone (42.2 vs 29.8) and was smooth with both drugs . post-intubation increases in heart rate, and systolic and diastolic blood pressures were attenuated by propofol when compared with thiopentone. After the administration of propofol, times to eye opening (6.4± 4.3 vs 13.9 ± 15.9 min), response to verbal command (7.6 ± 6.3 vs 15.4 ±16.6 rain) and orientation (22.7 ±12.8 vs 36.2 ±23.1 rain), were significantly shorter. Conclusion: Psychomotor and cognitive function returned earlier with propofol and fewer side effects were noted. At 24 hr there was no distinguishable difference between groups. Propofol is a safe anaesthetic agent with the potential for early patient discharge and street fitness after outpatient procedures.
Authors and Affiliations
Dr. C. M. S. Rawat
Keywords
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