PROSPECTIVE RANDOMISED COMPARITIVE STUDY ON EFFECTS OF ADDING DEXMEDETOMIDINE AND FENTANYL TO EPIDURAL BUPIVACAINE ON POST OPERATIVE ANALGESIA IN PATIENTS UNDERGOING LOBECTOMY.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 4
Abstract
Aim: To compare the duration and quality of postoperative analgesia between fentanyl and dexmedetomidine when added epidurally to bupivacaine in patient undergoing lobectomy. Materials and methods: After obtaining institutional ethical approval adult patients aged 18 to 60 years undergoing elective lobectomy with ASA PS II &III who have given valid informed consent patients were divided into two groups. Group D and group F. Group allocation was done by closed envelope method. Group D - received 8 ml of 0.125% bupivacaine and 1 mic/kg of dexmedetomidine diluted to 2 ml via the epidural catheter. Group F-received 8 ml of bupivacaine and 1 mic/kg of fentanyl diluted to 2 ml via epidural catheter. Result: This double-blinded prospective randomised controlled study was done to evaluate the duration of analgesia as well as sedation and adverse effects of dexmedetomidine (1 mic/kg) and fentanyl (1 mic/kg) given via epidural route with 0.125% bupivacaine in patients postoperatively who underwent lobectomy surgeries under general anaesthesia. This study analysed the duration of postoperative analgesia, quality of analgesia, the side effects and the hemodynamic changes which showed that dexmedetomidine was better than fentanyl in many aspects. Conclusion: In conclusion dexmedetomidine appears to have a beneficial effect as an adjuvant to local anaesthetic by improving the quality and increasing the duration of analgesia without the side effects associated with opioids like respiratory depression. It has minimal side effects and good hemodynamic stability, however its routine use in epidural route requires caution with regard to its effects due to central sympatholytic property and further studies are necessary to quantify the required dosage.
Authors and Affiliations
M. Bhavani
Keywords
Related Articles
- EP ID EP290555
- DOI 10.21474/IJAR01/6966
- Views 52
- Downloads 0
ASSESSMENT OF PREGNANCY RELATED STRESS AMONG WOMEN WITH SPONTANEOUS PREGNANCY(SP) AND IN VITRO FERTILIZATION/EMBRYOTRANSFER PREGNANCY(IVF/ET-P).
Introduction and background: A happy and trouble-free pregnancy is something thatall parents and practitioners might hope for, but for many couples this is not the reality and many women can experience stress at some poi...
HIGHER EDUCATION MANAGEMENT INFORMATION SYSTEM BASED WEBSITE AND MOBILE APPLICATIONS.
Electronic devices in the form of smartphones and tablets can now be used as information sources in an effort to build a management information system in universities. These electronic devices can shorten the distance be...
SCIENTIFICALLY PRACTICED INTERVENTIONS FOR AUTISM SPECTRUM DISORDER.
Autism is a complex neurological disorder that affects the functioning of the brain which means that it is a lifelong developmental disability that prevents people from understanding what they see, hear and otherwise sen...
A PROSPECTIVE, RANDOMIZED STUDY COMPARING THE ANTIEMETIC EFFECT OF INTRAVENOUS GRANISETRON AND ORAL GABAPENTIN IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERY IN ADULT.
Aim: To compare the efficacy of prophylactic intravenous administration of Granisetron 3mg versus Gabapentin 300 mg orally in preventing Postoperative Nausea and Vomiting in patients undergoing middle ear surgeries in ad...
TIME BASED SECURE DATA HANDLING IN PUBLIC CLOUD.
Data sharing in the cloud faces many challenges on security and privacy. Cloud computing is preferred as it reduces cost for data management and its available resources. To protect data from third party cloud server, it...