PROTECTIVE AND CURATIVE ACTIVITY OF ETHANOL LEAF EXTRACT OF CORCHORUS OLITORIUS IN THIOACETAMIDE EXPOSED RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
The present study was undertaken to evaluate the protective and curative effect of ethanol leaf extract of Corchorus olitorius against thioacetamide-induced toxicity in experimental rats. The animals were exposed to thioacetamide at a dose of 400 mg/kg body weight i. p for 3 selected days exhibited a significant increase (p < 0.05) in hepatic and renal biomarker enzymes namely; ALT, AST, ALP and increase concentration of bilirubin, urea and creatinine. Pre-treatment and posttreatment with extract of Corchorus olitorius at dose of 200 mg/kg body weight orally significantly decrease the hepatic and renal marker enzymes and concentration of bilirubin, urea and creatinine. The effects of Corchorus olitorius leaf extract on histological features of liver of experimental rats indicated that the normal control, extract pretreated and post-treated showed normal hepatic architecture while positive control group B shows occluded central vein and dilated sinusoids. Histopathological section of the kidney showed normal kidney stroma with Bowman’s capsule with glomerulus (renal corpuscle) and renal tubules, in pretreated, post-treated and normal control groups, while thioacetamide treated group showed infiltration of inflammatory cells. Present investigation showed that the ethanol leaf extract of Corchorus olitorius have considerable protective and curative effect against thioacetamide-induced hepatic and renal oxidative damages in rats.
Authors and Affiliations
Dr. Sule O. J.
GASTRIC EMPTYING AND PSYCHOPHARMACOLOGICAL EFFECTS OF NABAYAS LOUHA ON ANIMALS
Objective: The research work was carried out to characterize the gastric emptying and psychopharmacological effects of ayurvedic iron preparation ―Nabayas Louha‖ in swiss albino mice. Methods: Nabayas Louha was administe...
GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) ANALYSIS OF PHYTOCOMPONENTS IN THE ROOT, STEM BARK AND LEAF OF VERNONIA AMYGDALINA
Vernonia amygdalina is a medicinal plant widely used in traditional medicine in Africa and Asia for the treatment of ailments such as diabetes, inflammation, microbial infections and it has hypoglycaemic properties. The...
PALMEX: A THERAPEUTIC OPTION FOR MANAGEMENT OF LOWER URINARY TRACT SYMPTOMS IN MEN WITH BENIGN PROSTATIC HYPERPLASIA
Objective: A pooled analysis of clinical trials data of the effects of Palmex treatment on Lower Urinary Tract Symptoms (LUTS) in patients with Benign Prostatic Hyperplasia (BPH). Methods: The present analysis includes t...
DETECTION OF BACTERIOCIN GENE FROM KLEBSIELLA PNEUMONIAE
Bacteriocins are antimicrobial peptides produced ribosomally by Klebsiella species. They kill other members of the same or closely related species. The aim of this study was to detect bacteriocins gene in Klebsiella pneu...
CARDIAC TROPONIN AND CREATINE KINASE IN HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENTS ON ANTIRETROVIRAL DRUGS
People living with HIV are living a longer and productive life due to the effective viral suppression by highly active anti retroviral therapy (HAART). They are therefore exposed to metabolic syndromes associated with ag...