Protective Effect of Ethanol Extract of Celery (Apium graveolens L) on Kidney Damage in Ischemia/ Reperfusion Injury Rats Model
Journal Title: Molekul - Year 2019, Vol 14, Issue 1
Abstract
Ischemia/ reperfusion injury (IRI) is marked by the sudden decrease of blood supply to the kidney followed by restoration of blood flow. Ischemic acute kidney injury (AKI) is the leading cause of morbidity and mortality. Therefore, the prevention strategy for decreasing the damage due to IRI is required. Celery (Apium graveolens L) is often consumed as food. Celery has antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effect of the celery on kidney damage in the kidney ischemia/ reperfusion injury rat model. Twenty-five rats male, 2-3 months old Sprague Dawley were divided into 5 groups: Group 1 was sham operation, group 2 was ischemia/ reperfusion injury (IRI), group 3, 4, 5 were IRI and 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW of ethanol extract of celery respectively for 14 days before and 3 days after operation. Blood serum sample was taken 3 days after the operation for measuring urea, creatinine, superoxide dismuthase (SOD) and nitrite oxide (NO). Hematoxylin-eosin (HE) staining was utilized to examine kidney tubular injury score. Data were analyzed using One-way ANOVA (p<0,05). The ethanol extract of celery at dose 1000 mg/kgBW prevented the increase of urea, creatinine serum, kidney tubular injury score and prevented the decrease of SOD, NO in the kidney ischemia/ reperfusion injury rat model (p<0,05). In conclusion, the ethanol extract of celery has a protective effect on kidney damage in the ischemia/ reperfusion injury rat model.
Authors and Affiliations
Afifah Afifah, Khusnul Muflikhah, Viva Ratih Bening Ati, Rizki Maulana Tsani, Dairotul Khasanah, Watub Maulana
Keywords
Related Articles
- EP ID EP608743
- DOI 10.20884/1.jm.2019.14.1.448
- Views 113
- Downloads 0
Quantitative Analysis of Relationship Structure and Anionic Surfactant Micelle Concentration Critic With Semiempiris AM1
This research determines the mathematical equation which calculate the Concentration Micelle Critic theoretical anionic surfactant. The research was conducted the depiction of each surfactant anionic three-dimensional co...
STUDY ON THE FENTON REACTION FOR DEGRADATION OF REMAZOL RED B IN TEXTILE WASTE INDUSTRY
Remazol Red B is a reactive dye that is often used in the textile industry. The dye can cause serious problems in the environmental / water because it is difficult to be degraded by microorganisms. Decolorization of reac...
Gene Expression Changes and Anti-proliferative Effect of Noni (Morinda Citrifolia) Fruit Extract Analysed by Real Time-PCR
To elucidate the anti-proliferative effect of noni (Morinda citrifolia) fruit extract for a Saccharomyces cerevisiae model organism, analysis of gene expression changes related to cell cycle associated with inhibition ef...
The Interaction of Air Pollutant Molecules with Germanene and Silicene: a Density Functional Theory Study
We investigate the adsorption of atmospheric pollutants on germanene and silicene using density functional theory (DFT) calculations. In this study, we use carbon monoxide (CO) and nitric oxide (NO) as the pollutant mole...
Colorimetric Detection of Hg(II) Ion Using Silver Nanoparticles Capped with 3-Hydroxybenzoic Acid
In this paper, we report for the first time thesimple method for detection of Hg(II) ion in anaqueousmedium using silver nanoparticles capped with 3-hydroxybenzoic acid. Silver nanoparticles capped with 3-hydroxybenzoic...