PROTECTIVE EFFECT OF ROSA CANINA L. ON STRESS INDUCED REPRODUCTIVE CHANGES IN FEMALE RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 2
Abstract
Here we evaluate the aqueous extract of Rosa canina L. hips in treating female reproductive dysfunctions. Restraint stress (for 3h/day for 28 days) was used as stressor to induced changes in reproductive dysfunctions. Rats were pretreated with 100mg/kg body weight and 200mg/kg b.w. for 15 days with Aqueous extract of Rosa canina L. hips and were continued for next 28 days along with induction of stress. Assessment of its effectiveness was done by observing changes in estrous cycle and weight of the organs studies. Rosa canina L. treated rats showed significant changes in the different phases of estrous cycle and restored to normal. Improvement in the weight of ovaries, uteri, liver and decrease in the weight of adrenal glands were also seen when compared with stressed control. From the experimental studies, aqueous extract of Rosa canina L. hips at two different doses showed promising improvement in treating female reproductive dysfunctions induced by restraint stress. The above activity may be due to the presence of various secondary metabolites like ascorbic acids, tocopherols, bioflavonoids, tannins, flavonoids, alkaloids and other constituents present the in Aqueous extract of Rosa canina L. hips
Authors and Affiliations
Santosh Gupta, Amit Gupta, Dhirendra Prakash, A. K. Gupta, Vedpal
Keywords
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