PROTECTIVE EFFECT OF SPIRULINA ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The aim of our present study is to assess the effects of spirulina as a preventive agent in experimentally induced urolithiasis model in rats. Rats were induced to produce kidney stone by providing drinking water containing 0.75% ethylene glycol (v/v) (EG) for 6 weeks. In additiion to this, spirulina extract 20mg/kg, were administered along with ethylene glycol for 6 weeks. On 24 hours after 6 weeks, the blood was collected from individual rats and used for the estimation of sodium, potassium, chloride, calcium, phosphorus, urea and creatinine. The ethylene glycol feeding resulted in an increased level of serum sodium, potassium, chloride, calcium, urea and creatinine, with a decreased level of phosphorus, compared to normal rats. All these conditions were reversed on spirulina treatment. Histopathological analysis also showed that rats treated with ethylene glycol had large deposits of calcium oxalate crystals, and that deposits were reduced in rats treated with spirulina. These data suggest that spirulina has a protective activity against urolithiasis.
Authors and Affiliations
J. Sunitha , S. Asha , G. Taju
Keywords
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