Protective Role of Olive Oil and Polyherbal Drug on Renal Dysfunction Induced by Dexamethasone in Albino Rats
Journal Title: Journal of Contemporary Medicine and Dentistry - Year 2018, Vol 6, Issue 2
Abstract
This study was plan to evaluate the biochemical effects of olive oil and polyherbal drug against dexamethasone-induced renal dysfunction in a male albino rat. Male rats (20) were divided into four equal groups: Group 1: rats were injected subcutaneously with normal saline and consider as normal control. Group 2: rats were injected subcutaneously with dexamethasone (0.1 mg/kg body weight). Group 3: rats were injected dexamethasone (0.1 mg/kg body weight) subcutaneously, and then treated with olive oil (200 mg/kg body weight) by oral gavage. Group 4: rats were injected subcutaneously with dexamethasone (0.1 mg/kg body weight), and then treated with the polyherbal drug in a dose of 200 mg/kg body weight by oral gavage. After 3 weeks, serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) activities,blood urea nitrogen (BUN) and creatinine levels were estimated. Administration of dexamethasone caused elevation of serum levels of Creatinine, BUN,, ALT, AST, Glucose, Hb1Ac and Albumin activities. Treatment with Olive oil and polyherbal drug showed a significant increase in the body weight of rats in the group treated with olive seed extract orally compared with the dexamethasone control group. Olive oil and polyherbal drug positively affect dexamethasone-induced renal alteration in albino rats.
Authors and Affiliations
Mohd Adnan Kausar, Abdullah Selmi Suliman Alfarsi2, Raed Alasmer \Alenzi, Fisal Fahad Owined Alshammary, Hani Abdulrhman Zabin Almutairi, Nasser Abdulrhman Ibrahim Al-Tamimi, Abdalaziz Fahad Saleh Alanizy, Abdulrhman Fahad Alrashedy, Abdullah Hazza Alhobera, Mohammed Mohi Almasoud, Mohammed Qumani Ahmed, Saeed Ahmed, Tarig Nasser, S. M. A. Shahid
Keywords
Related Articles
- EP ID EP482490
- DOI -
- Views 123
- Downloads 0
Biphosphonates Related Osteonecrosis: Prevention and Treatment Possibilities
Background: Bisphosphonates are a group of antiresorptive drugs used mainly for patients with osteoporosis, multiple myeloma, Paget’s disease. Their high affinity to bone mineral and ability to inhibit bone turnover some...
Utility of 3D Printing in Byzantine Spinal Surgeries: A Review
3-dimensional printing (3DP) is an unexpectedly developing enterprise. A spread of techniques can be used to print physical models from 3-dimensional renderings based on CAD software, and STL design files. Even as using...
Infections in a Multi-Disciplinary Intensive Care Unit with Special Reference to Blood Stream Infection
Objectives: To study the incidence of Blood Stream infections (BSI) in the ICU, to identify the predictors, to study the bacteriological profile and their antibiotic sensitivity patterns and to correlate the incidence of...
Lattissimus Dorsi Tendon Transfer in Irreparable Postero-Superior Cuff Tears: Present and Future
Postero-superior cuff tears (PSCTs) are the most difficult hitch of all the cuff tears especially those which are vast and irretrievable. About 30% of the mended rotator cuff are constituted by vast PSCTs, while irretrie...
Functional Outcome of Plating versus Nailing in Adult Midshaft Radius-Ulna Fractures
Objectives: Study regarding mode of injury and restore anatomical alignment. Comparison of various functional parameters among study group post-operatively. Methods: Study was conducted by collecting data of 90 adult cas...