PROTECTIVE ROLE OF PUNGANUR COW URINE ON STREPTOZOTOCIN INDUCED DIABETES IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 8
Abstract
Punganur Cattle is the world’s smallest Bos indicus cattle originated in Punganur town in Chittoor district of Andhra Pradesh, India. This breed is known for its short stature, high milk production efficiency and efficient reproductive characters. In Ancient Ayurvedic scriptures such as Charaka samhita, Shushruta samhita and Brahad-Wagbhatt mention various medicinal properties of cow urine. It is used as an insecticide and in disorders like intestinal gas, acidity and cough. Although Indian Ayurvedic literature cites many medicinal properties of cow urine, there is no scientific evidence to support this. Hence, the present study was aimed to evaluate the antidiabetic activity of cow urine was undertaken. The effect of a distillate of cow urine was studied in vivo in rats given streptozotocin. Diabetes was induced by administration of streptozotocin (50 mg / kg body wt., i.p). The antidiabetic effect of three different doses and a standard drug, Glibenclamide (0.25 mg/kg, p.o), was studied in diabetic rats. Fasting blood glucose levels, serum lipid profiles, liver glycogen levels and initial and final changes in body weight were assessed. The cow urine distillate produced a significant (P < 0.05) reduction of the elevated blood glucose, serum cholesterol and serum triglycerides levels when compared with the diabetic control. The diabetic animals treated with cow urine distillate also showed a significant increase in HDL levels and a gain in body weight when compared with the diabetic control. Earlier studies have revealed the presence of antioxidants and free radical scavengers in cow urine which might be responsible for anti- diabetic effects. The present communication records the first ever report on protective role of cow urine on diabetic in a bizarre situation of tropical climate of Andhra Pradesh (AP), India.
Authors and Affiliations
M. Vijaya Reddy, A. Karthik, P. Sasikala
Keywords
Related Articles
- EP ID EP87721
- DOI 10.7897/2230-8407.04832
- Views 165
- Downloads 0
ANTIDIABETIC ACTIVITY OF JATROPHA GOSSYPIFOLIA LINN ROOT EXTRACTS IN ALLOXAN INDUCED DIABETIC MICE
Diabetes is most common endocrine disease which exists globally and interests about 6 % of the world population. The recommendation of W.H.O. about diabetes has led to a rise in investigation of medicinal plants for hypo...
ROOT AND ROOT CANAL MORPHOLOGY AND ITS VARIATION OF THE HUMAN MANDIBULAR CANINE: A LITERATURE REVIEW
The objective was to review the literature of the root and root canal morphology of the human Mandibular canine. Published studies cite the anatomy and morphology of the mandibular canine tooth. Individual case reports o...
ANTINOCICEPTIVE ACTIVITY OF SRI LANKAN BLACK TEA BREW (CAMELLIA SINENSIS L.) IN RATS
The aim of this study was to investigate the antinociceptive potential of warm black tea brew of Camellia sinensis (L.) O. Kuntze (Theaceae). This was tested in rats using high grown Sri Lankan Dust grade No: 1 black tea...
ANTICANCER POTENTIAL OF METHANOLIC AND AQUEOUS EXTRACT OF LEUCAS INDICA (LINN.) AGAINST EHRLICH ASCITES CARCINOMA CELLS ON SWISS ALBINO MICE
The present study was designed to evaluate the in vivo anticancer activity of methanolic and aqueous extract of Leucas indica Linn. (Aerial parts) against Ehrlich’s Ascites Carcinoma (EAC) on Swiss albino mice. The antic...
DEVELOPMENT AND VALIDATION OF RP-HPLC ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF PHENTERMINE AND TOPIRAMATE IN PURE AND ITS PHARMACEUTICAL DOSAGE FORMS
Developing a single analytical method for estimation of individual drug from a multidrug composition is a very challenging task. A simple, rapid, precise, and reliable simultaneous stability indicating RP - HPLC method...