Proteomics Tools for Oral Cancer Biomarker Discovery
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Proteomic study of human body fluid (saliva and serum) holds assure as a non-invasive method to identify biomarkers for human oral cancer. The evolving of novel technologies allows researchers to aid the inclusive analyses of proteomes in cancer. The protein expression pattern of tumors cells measure by proteomics technologies that provide opportunities to discover potentially new biomarkers for the early detection and diagnosis of oral cancer. Different proteomic tools such as 2DPAGE, 2D-DIGE,MALDI, SELDI-TOF-MS LC-MS/MS technology, protein arrays, iTRAQ, ICAT and MudPIT have been used for discrepancy analysis of various biological samples, including cell lysates, Saliva, serum, plasma and tumors tissue to better understand the molecular foundation of cancer pathogenesis and the validation and characterization of disease-associated proteins. This review covers a selection of advances in the dominion of proteomics and its promise for oral cancer biomarker discovery. It also introduces sample preparation and discusses current challenges that need to be defeat and the efforts of the Early Detection of oral cancer and promoting biomarker discovery for conversion at the clinical level.
Authors and Affiliations
Nishant Sharma, Dr . B. R Srivastav, Dr. Archana Shrivatav
Keywords
Related Articles
- EP ID EP222249
- DOI -
- Views 101
- Downloads 0
Method Development And Validation For Simultaneous Estimation Of Quercetin And Rutin In Bark Of Saraca Asoca And Herbal Formulation By HPTLC
A simple, accurate and precise High-performance thin layer chromatography (HPTLC) method was developed and validated for the simultaneous determination of Quercetin and Rutin in the methanolic extract of bark of Saraca a...
MANAGEMENT OF STRESS: A REVIEW
Abstract This review aimed to assess the stress. Stress is a fact in our daily life. when a person needs help, it means it means that persons feel that personally and emotionally disabled. Most people believe that their...
“INFLUENCE OF NSAIDS ON BLOOD PRESSURE IN HYPERTENSIVE PATIENTS UNDER TREATMENT: A CROSS SECTIONAL STUDY”
Raised blood pressure is one of the leading risk factors for global mortality and is estimated to have caused 9.4 million deaths. There are chances of using anti-hypertensives and NSAIDs together with increasing age for...
FORMULATION AND DEVELOPMENT OF STABLE DOSAGE FORM OF AMLODIPINE BESYALTE AND BENAZEPRIL HYDROCHLORIDE TO OVERCOME PHYSICAL INCOMPATIBILITY
Abstract Amlodipine is a dihydropyridine calcium channel blocker with a slow onset and long duration of action. Benazepril hydrochloride is an angiotensin- converting enzyme inhibitor. But the Amlodipine besylate and Ben...
EFFECT OF HYDROGEN SULFIDE SYNTHESIS ENZYME INHIBITION BY ESTIMATION OF MUCIN IN PSYCHOLOGICAL STRESS-INDUCED ULCERS IN MICE
Abstract Objective: The present study was undertaken to evaluate the effect of Hydrogen Sulfide synthesis blocker induced enzyme inhibition by estimation of mucin in Psychological Stress-Induced Ulcers in Mice. Material...