Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) in Type 2 Diabetes Mellitus, a Case Control Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 8
Abstract
Introduction: Diabetes mellitus (DM) is characterized by hyperglycemia accompanied with the biochemical alterations in carbohydrate, protein and lipid metabolism. Diabetics have been shown to be in procoagulant state due to abnormalities in several plasma proteins in blood coagulation.Measurement of prothrombin time (PT), activated partial thromboplastin time (APTT), bleeding time and clotting factor concentration are usually done in patients with a suspected abnormal coagulation. The present study was planned to assess and compare the coagulation tests in patients with T2DM and healthy individuals. Material and methods: In this prospective case control study 50 diabetic patients and 50 healthy non-diabetic individuals were were subjected to Prothrombin time(PT), Activated partial thromboplastin time(APTT) and D-Dimer assay patients in the department of Pathology at Adesh Institute of Medical Sciences and Research, Bathinda from 1st January 2016 to 30TH June 2017. Results: A stastically significant increase in Mean Prothrombin time (PT) levels of 17.48 in cases vs 14.52 in controls with a P value was 0.012. The Mean aPTT levels in cases was 48.12 and in controls was 30.56 with a P value was 0.001. However, in case of Mean D-Dimer levels, there was no significant difference between cases and controls with a P value of 1.000. Conclusion: The present study observed a significant association between Type 2 Diabetes mellitus and coagulation parameters. Increased plasma levels of PT and APTT were observed which are consistent with abnormal coagulation mechanisms and may be interpreted as a tendency for bleeding and cardiovascular disorders. It would also be helpful to incorporate coagulation screening as a routine investigations for the better management of diabetic patients.
Authors and Affiliations
Shaffy Thukral, Saleem Hussain, Shuaeb Bhat, Navleen Kaur, Asritha Reddy
Keywords
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