PROTON MAGNETIC RESONANCE SPECTROSCOPY STUDY IN FRONTAL WHITE MATTER OF PATIENT WITH MAJOR DEPRESSIVE DISORDER
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 30
Abstract
BACKGROUND Depression is one of the major problems of modern society and 350 million people worldwide are suffering from MDD. The purpose of this study was to examine the biochemical characteristics of the bilateral frontal white matter of first-episode, treatment-naive, non-late-life adult patients with MDD and healthy controls by using single-voxel 1H MRS. METHODS We included 45 MDD patients (24 male and 21 female), 20 healthy controls (12 males and 8 females). There were no significant differences in sex, age, and education status between the MDD group and the healthy control group. MRS scanning was performed on both the control and patient groups. RESULTS Study showed the means of the metabolite ratio in the bilateral frontal white matter in major depressive patients and healthy controls the NAA/Cr and Choline/Cr ratio was found to be significantly decreased in major depressive disorder patients compared with the healthy control subjects. Furthermore, there was no significant correlation between the metabolite ration and HDRS score or the illness duration. CONCLUSIONS Findings suggest that the biochemical abnormalities in prefrontal white matter, especially in the left dorsolateral white matter, may occur early in the course of MDD and may be related to the neuropathology of depression.
Authors and Affiliations
Hari Singh, Vandana Verma, Vineet Modi, Sanjeev Kumar, Abhay Kumar, Neeraj Kumar, Utkarsh Yadav
Keywords
Related Articles
- EP ID EP670357
- DOI 10.18410/jebmh/2019/409
- Views 97
- Downloads 0
STUDY OF CLINICAL PROFILE AND DIFFERENTIATING SYSTOLIC AND DIASTOLIC HEART FAILURE BY ECHOCARDIOGRAPHY
BACKGROUND Heart failure is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. The primary manifestation of heart failure is dyspnoea and fa...
CYTOLOGICAL EVALUATION OF MALE BREAST LESIONS IN GREATER GWALIOR: A FIVE YEAR RETROSPECTIVE STUDY
BACKGROUND: Fine needle aspiration cytology is an effective modality for diagnosis of breast lesions. Usually male breast lesions are benign and affect the young male. Most common lesion is gynaecomastia. Male breast can...
LETROZOLE VERSUS CLOMIPHENE CITRATE IN OVULATION INDUCTION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
BACKGROUND Polycystic ovarian Syndrome (PCOS) is a chronic condition with manifestations that begin most commonly in adolescence with menstrual irregularity and hyperandrogenism, with a transition over time into problems...
A COMPARATIVE STUDY OF CENTRAL FOVEAL THICKNESS PRE AND POST CATARACT SURGERY USING SD-OPTICAL COHERENCE TOMOGRAPHY
BACKGROUND The purpose of this study is to compare central foveal thickness (CFT) of patients preoperatively and postoperatively cataract surgery using SD- optical coherence tomography and to correlate CFT with vision. M...
TO EVALUATE CLINICALLY THE OUTCOME OF LICHTENSTEIN REPAIR FOR INGUINAL HERNIA IN A TERTIARY CARE CENTRE
BACKGROUND The first hernia repair was done by Bassini 100 years ago and all the next surgical methods and their modifications use a suture of the tissues under the tension. Lichtenstein technique challenged the concept...