Pseudo alteration of Coagulation Profile- In vivo Biochemical reactionary effect of Fresh Frozen Plasma after Infusion
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Aims & Objective: The use of fresh frozen plasma (FFP) continues to rise, despite the fact that the supply of plasma derived from allogenic blood donation is finite. The safety and effectiveness of transfusion depend on the appropriate clinical use of blood and blood products. This study was evaluated of coagulation profile in various common disease conditions and conducted to review the effect of FFP transfusion on coagulation profile (INR). Methodology: A retrospective study of blood bank records and coagulation profile results of the patients given FFP from September 2006 to August 2007, in Gandhi Medical College and Hospital, Bhopal was undertaken. The criteria set by the department of pathology were used as the guidelines. Results: Total 1064 coagulation studies were performed and 481 were deranged results (exclusive of CTICU and ICCU patients). Out of that 112 was in pediatric patients 16 patients was non pediatric illness, 105 in emergency medicine, 70 in surgical,177 in medical 11 in gynecologic and 19 was unclassified patients (Burn, orthopedics).Total 874numbers of patients to which FFP were supplied. 1.70 FFP units supplied per patient. Pediatric patients were 345 and 529adult and elderly. An in depth analysis of the rationale behind prescribing FFP to each patient was made. Every possible justification was sought from the clinician for prescribing FFP. Conclusion: FFP is a vital component of blood, not just a substitute. Although very useful clinicopharmacologically, FFP also carries potential adverse effects. Clinicians must abide by the rules and guidelines that exist pertaining to its rational usage. A clinician may have a thousand things in mind but the transfusion personnel are more competent in dealing with the use of components. Let the clinicians know about the indications and usage of blood component, particularly FFP. Even if the indication for FFP is clinically valid, suggest the clinician to be wise still in using the component. Stop the practices that may encourage the irrational use of blood products
Authors and Affiliations
Dr C. S. Chhatrasal
Keywords
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