Pulmonary Function Tests and Diffusion Capacity in Type 2 Diabetes and Their Possible Correlation with Proteinuria
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 12
Abstract
Background-Type 2 diabetes mellitus is known to cause serious progressive macro and micro vascular complications leading to end organ damage like retinopathy, nephropathy and neuropathy. Pulmonary complications due to collagen and elastin changes as well as microangiopathy has also been demonstrated in type 2 diabetes mellitus but prevalence in most of population is unknown and its possible correlation with proteinuria is not studied more. Aims And Objectives- To compare pulmonary function tests (PFT) and diffusion capacity for carbom monoxide (DLCO) in type 2 diabetes mellitus with control group and to evaluate possible correlation of PFTs and DLCO with proteinuria. Methods-Consecutively consenting 120 subjects who satisfied the inclusion criteria were recruited over one year duration. These 120 subjects are categorised into two i.e. healthy volunteers recruited as controls (n=60) and type 2 diabetic patients (n=60). Results- Both group compared and studied with each other. Diabetic patients showed a significant reduction in Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC) and pulmonary diffusion capacity for carbon monoxide (DLCO) relative to their matched controls and these values were further reduced in patients with diabetic nephropathy. Conclusions- Our study concludes that lung functions in type2 diabetes mellitus was impaired and there was restrictive pattern of respiratory abnormality. The mean reduction in FEV1, FVC and DLCO was more in diabetes as compared to their matched controls and these lung functions were further reduced in patient with diabetic nephropathy. Duration of diabetes did not influence on pulmonary functions.
Authors and Affiliations
Jitendra Singh
Keywords
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