QUANTIFICATION BIAS IN BLOOD ALCOHOL DETERMINATION BY HEADSPACE GAS CHROMATOGRAPHY
Journal Title: International Journal of Medical Laboratory Research - Year 2019, Vol 4, Issue 1
Abstract
The quantification of blood alcohol concentration is routinely performed in many forensic laboratories by gas chromatography. In this short report, the influence of the matrix miss-match between samples and calibrators (e.g. the use of aqueous standards to quantify blood samples) and the actual efficiencies of different internal standards used to normalise the ethanol signal were considered. Test samples in blood and water were prepared from a certified reference standard of ethanol. The samples were analysed by gas chromatography using n-propanol and t-butanol as internal standards. The collected data provided evidences that a sub-optimal setting of the considered variables can be responsible for a quantification bias up to 15%. These issues are of practical relevance in the medico-legal sector and should be considered during the process of method development.
ACUTE PROMYELOCYTIC LEUKEMIA (APL): DIAGNOSIS AND TREATMENT
Background:Acute Promyelocytic Leukemia (APL) is a subgroup of Acute Myeloid Leukemia(AML) with a different certain clinical period, biology and treatment. APL was the deadly leukemia but today it is most curable leukemi...
IS RESISTANCE TO ETHIONAMIDE AN EXTRAPOLATION OF OTHER FIRST AND SECOND LINE ANTI- TUBERCULOSIS DRUGS?
Drug Susceptibility profile of ethionamide and other first and second line anti tuberculosis drugs revealed no significant association, indicating the resistance towards ethionamide is the result of individual effect and...
IRON POISONING WITH ANALYTICAL ASPECTS AND ITS MANAGEMENT
Iron is a naturally occurring element found in the nature. It is denoted by the symbol Fe and has an atomic number 26. Iron is one of the most common metals occurring on earth. It occurs in a variety of oxidation states....
QUALITATIVE AND QUANTITATIVE ANALYSIS OF BILIARY CALCULI IN A TERTIARY CARE HOSPITAL
Background :- Gallstone disease remains a serious health concern for human beings, affecting millions of people throughout the world. Material and method:- The cross sectional study was conducted in department of Biochem...
THE RELATIONSHIP BETWEEN MALNUTRITION, IMMUNITY AND MALARIA TRANSMISSION IN CHILDREN
: Malaria is one of the major causes of sickness and death in sub-Saharan Africa. It is responsible for 1•5–2•7 million deaths each year in sub-Saharan Africa, of which at least 0•7 million are among children aged under...