Quercetin A potential treatment for keloids
Journal Title: Sultan Qaboos University Medical Journal - Year 2019, Vol 19, Issue 4
Abstract
Plant secondary metabolites are chemically diverse compounds, some of which have been largely exploited as pharmaceuticals, food additives and flavours. Flavonoids and other phenolic compounds constitute one of the main classes of secondary metabolites.1,2 As one of the most abundant form of flavonoids, quercetin (3,3’, 4’, 5,7-pentahydroxyflavone) has been receiving much attention owing to its potential antioxidant, anti-allergic, antiinflammatory, anti-cancer, anti-diabetic, anti-microbial and cardio-protective properties.1 Keloids are exuberant overgrowths of scar with excessive fbroblast proliferation and matrix deposition, which has the ability to spread beyond the original boundary of the wound.3 Despite existence of a wide array of therapies available for keloids, no treatment is yet considered completely effective. Corticosteroids, surgical excision, silicone sheeting, cryosurgery, radiotherapy, laser therapy and photodynamic therapy have been extensively applied to treat keloids.4 Other promising approaches such as mesenchymal stem cell therapy, fat grafting, electrical stimulation, and deployment of RNA interference seem to be benefcial for the treatment of keloids.5 Over the past years, studies found compelling evidence that indicate the advantageous properties of quercetin as a potential candidate for adjuvant therapy of keloids.
Authors and Affiliations
Hamideh Moravvej, Mojtaba Memariani, Hamed Memariani
Keywords
Related Articles
- EP ID EP675789
- DOI http://dx.doi.org/10.18295/squmj.2019.19.04.015
- Views 303
- Downloads 0
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