Radiation-induced Testicular Injury and Its Amelioration by Telfairia occidentalis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 12
Abstract
Aims: The radioprotective effect of Telfairia occidentalis aqueous extract (TOE) against gamma irradiation induced oxidative damage and altered sperm parameters in rats. Study Design: Randomized controlled experiment Place and Duration of Study: Experimental Animal Unit and Department of Anatomy, University of Ibadan between January and April, 2012. Methodology: Male Wistar strain rats were divided into six groups and pretreated with TOE (400, 800 and 1600 mg/kg of b.wt.) and vitamin E (VE) 50 mg/kg of b.wt prior to whole body gamma irradiation exposure of 2Gy. Sections of the testes were taken for the assessments of biochemical markers of oxidative stress: Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) and histopathological variations. Results: Exposure of animals to 2Gy gamma radiation resulted in decreased sperm characteristics and increased sperm morphological abnormalities; significant elevation in lipid peroxidation (LPO) and hydrogen peroxides, and decreased activities of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GSH-Px) and levels of reduced glutathione (GSH) in testes; distorted architecture of seminiferous tubules from day 1 to 30 post-irradiation. The rats pretreated with TOE showed normal sperm parameters, normal testicular histo-architecture and normal antioxidant enzymatic activities. Conclusion: Aqueous extract of Telfairia occidentalis has radioprotective activities.
Authors and Affiliations
S. A. Adejuwon, J. O. Omirinde, A. P. Ebokaiwe, O. O. Aina, A. Adenipekun, E. O. Farombi
Keywords
Related Articles
- EP ID EP348945
- DOI 10.9734/BJMMR/2014/8235
- Views 98
- Downloads 0
Clinical and Immunological Evaluation of Application of Ronkoleukin in Nonspecific Vulvovaginitis at Adolescent Girls
Package Insert: According to immunological parameters there was found that during the sub-acute there is the secondary immune deficiency and the immunodeficiency is absent during the acute. During the acute phagocytic f...
Long-term Weight Changes and Subsequent Hypercholesterolemia in Chinese Population
Aims: To explore the relationship between long-term body weight changes and hypercholes-terolemia in middle aged Chinese population. Study Design: Population based cross-sectional study. Place and Duration of Study: Depa...
Campylobacter Data in Childhood from a University Hospital
Background and Objectives: Due to underdiagnosis because of the technical difficulties plus inadequacy of laboratories, actual incidence of campylobacteriosis may substantially be greater than the reported incidence in m...
Cost Benefit Alternative to Single Access Laparoscopic Cholecystectomy
Introduction: Single-incision laparoscopic surgery is an attractive approach for cholecystectomy. However, its widespread application has many limitations. A significant obstacle of application in developing countries is...
Effect of a Nurse-led Training Programme on Pressure Injury Prevention and Treatment among Nurses in Two Teaching Hospitals in Ogun State, Nigeria
Aims: Pressure injury is a common health problem associated with rise in treatment cost and lengthy hospital stay. Despite advancements, trainings and researches on pressure injury prevention and treatment, its knowledge...