Randomized Comparative Study of Drug Regimens: Fentanyl with Propofol and Fentanyl with Midazolam as Sedating Agents in Day Care Oral Surgery
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 6
Abstract
Introduction: Widespread use of general anesthesia is limited by the risk associated, requirement of adequate equipment, extensive training required, and the cost. The use of intravenous agents in conjunction with local anesthetics has a definite synergistic effect and is referred to as conscious sedation. Aim: The aim of this study is to compare usefulness and toxicity by qualitative comparison between two combinations, fentanyl + propofol, and fentanyl + midazolam, as agents for conscious sedation in patients undergoing maxillofacial surgical procedures. Materials and Methods: The present study was conducted on 10 adult patients, 5 in each group (fentanyl + propofol and fentanyl + midazolam), between 14 and 50 years of age irrespective of sex. The comparison was made in terms of onset of action, recovery anterograde amnesia, patient cooperation, surgeons’ convenience, side effects, and other parameters. Result: Although the therapeutic efficacy of both the combinations was satisfactory, fentanyl + propofol combination showed better amnesic property and tolerance to the surgical procedure, whereas fentanyl + midazolam combination showed greater respiration depression. Fentanyl + propofol was found to be superior sedating agent having rapid onset and predictability of action, profoundness of amnesia, and faster recovery periods, offering advantage of early patient discharge and better patients compliance agent in day care maxillofacial surgical procedures. Conclusion: Propofol + fentanyl combination as a superior sedating agent compared to fentanyl midazolam combination having rapid onset and predictability of action, profoundness of amnesia, and a faster recovery period, offering advantages early patient discharge and better patient compliance.
Authors and Affiliations
G Suresh Kumar, D Karthikeyan, Heber Anandan
Keywords
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