Ratio of Follicle Stimulating and Luteinizing Hormone with Hormones of Implantation in Intracytoplasmic Sperm Injection
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Objective: To assess relationship of ratio of follicle stimulating (FSH) and luteinizing hormone (LH) with hormones of implantation in females down-regulated for Intracytoplasmic sperm injection (ICSI). Material & Methods: Retrospective study of 564 primary infertile females booked for ICSI from June 2012 till August 2014 was carried. They were 20-40-years old with infertility of more than two years and body mass index 18-35kg/m2 . FSH and LH were assessed before and Estradiol (E2) and Progesterone (P) after down regulation of ovaries by enzyme linked Immunosorbent assay. Logistic regression was applied for clinical pregnancy (CP) with FSH, LH and its ratio. Median value of variables with best results after regression was used for stratification of groups. Hormones of implantation; E2, P and their ratios were compared in the derived groups. Results: On the basis of highest Beta error, groups was stratified as;group I ≤ 1.26 and group II > 1.26 median value of FSH/LH ratio. The CP rate was 36% with higher number of pregnancies 158 /286 (55 %) in Group I as compared to 44/278 (16%) in group II. Group I females had high peak and mid luteal E2 and low P as compared to other group (p<0.001). Linear correlation of FSH/LH was observed with E2/P (r=-0.250, p<0.001). Conclusion: High E2/P ratio required for CP in stimulated cycles was acquired by females with low FSH/LH ratio measured before down regulation of ovaries.
Authors and Affiliations
Dr. Faiza Alam
Keywords
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