Rationale of method of analysis of evidence-based data on the pharmacological activity of succinic acid and its combinations drugs
Journal Title: Фармацевтичний журнал - Year 2015, Vol 6, Issue 6
Abstract
Succinic acid as endogenous metabolite has a wide range of applications in medical practice in Ukraine and abroad. We research a new medicines, based on succinic acid, ascorbic acid and rutin for the prevention and treatment of influenza. Analysis of the data evidence-based medicine necessary for the implementation of quality assessment study feasibility of adding succinic acid in the various dosage forms and determine their pharmacological activity. It was studied international databases and registers of clinical trials MEDLINE®, EMBASE®, Scopus, Cochrane Library for the period from 1966 to June 2015. In the search for key phrases search engine electronic library «The Cochrane Library» found 872 913 publications, including 71 in the section «Trials». Of these, only 23 were devoted to review the results of clinical trials of medications that contain in their composition succinic acid. In the analysis of papers revealed that all 12 Trials of the search engine PubMed are present in search results «The Cochrane Library». Therefore, for further analysis we selected directory search results Trials «The Cochrane Library» and 3 Review of retrieval system PubMed. We analyzed Trials in terms of pharmacological activity and dynamics of publications. For pharmacological properties and relevance RCTs grouped as follows: antihypoxic action confirm 7 RCT (2003–2013 years), improve of iron absorption in the gastrointestinal tract – 6 RCT (1966–1974 years), hepatoprotective – 4 RCT (2013–2014 years). One RCT has effectiveness succinic acid for use in gastroenterology (in combination with omeprazole, 2012), depression (2013), the transplant (1993) during menopause (2008), renal failure (2013) for fever during surgery (2007). We can call such medicines containing succinic acid and have proven clinical efficacy: Remaksol, Tsytoflavin, Vecam (Omeprazole + succinic acid). We analyzed the Review of reviews of retrieval system PubMed. Analysis reviews MedLine (Review) opens new prospects for the use of succinic acid in the treatment of hypoxia and viral hepatitis. The results of clinical trials confirm the feasibility of developing new drugs with succinic acid. We conducted a review of evidence data about the inclusion of succinic acid in the various dosage forms. Succinic acid is the part of the drugs with different pharmacological effect. The results of clinical trials confirm the feasibility of developing of new drugs with succinic acid.
Authors and Affiliations
M. V. Leleka, O. M. Zaliska
Keywords
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