RECENT ADVANCE IN ANTI-CANCER ACTIVITY OF INDOLE DERIVATIVES
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 4
Abstract
Indole is a bicyclic aromatic heterocyclic organic compound comprising of a six membered benzene ring fusedto a five-membered nitrogen-containing pyrrole ring. It is an excellent scaffold in drug discovery which provides numerous opportunities in the discovery of novel drugs with different mechanism of action. It has a very unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. A vast research has occurred on indole and its derivatives which resulted in many approved indole containing drugs in the world market as well as many are in the pipeline stages. The recent identification of an indole analog as a potential new anticancer lead. Indole nucleus is continuously drawing interest for development of newer drug moiety due to its wide range of activities like anticancer, antibacterial, antifungal, anti-malarial, anticonvulsant and anti-inflammatory. The research is going on in nucleus. In recent years, a wide range of research has been done in the field of anti-cancer drug development. Since indole nucleus has shown quite good response as an anticancer agent, hence this nucleus has become an interest in the field of research. Indole is present in Vinca alkaloid which can be used as an anti-cancer agent. So keeping in mind this point indole has been used for better anti-cancer activity of target compound. This review was focused on the indole and its derivatives that are now in development.
Authors and Affiliations
C. Buvana
Keywords
Related Articles
- EP ID EP620541
- DOI -
- Views 127
- Downloads 0
EVALUATION THE RISK FACTOR OF BREAST CANCER AMONG WOMEN IN AL-ELWIYAH TEACHING HOSPITAL IN BAGHDAD/ IRAQ
Introduction: - Iraq suffers from the pollution of water, air, and soil caused by the emissions of cars and generators in crowded areas, and excessive use of chemical fertilizers, in addition to the remnants of war and d...
THE REVIEW OF LAVANA KALPAS ACCORDING TO SUSHRUTACHARYA W. S. R. TO VATA VYADHI CHIKITSA
In Ayurveda Various basic formulations have been mentioned in the classical texts i.e. Samhitas and quite a few were added later on, by contemporary Acharyas. Lavana Kalpana is one of them. In Ayurveda Pharmaceutics broa...
A PROSPECTIVE STUDY TO EVALUATE THE PRESCRIBING PATTERN OF DRUGS IN PATIENTS WITH ISCHEMIC STROKE AND ROLE OF MEMANTINE IN POST- STROKE APHASIA.
Stroke is a clinical syndrome characterized by rapidly developing clinical symptoms and / or signs of focal, and at times global (applied to patients in deep coma and those with subarachnoid hemorrhage), loss of cerebral...
SYNTHESIS AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES LOADED CARICA PAPAYA LEAVES EXTRACT AND TEST OF THEIR ACTIVITY IN KILLING OF YELLOW SNAILS
In this study, chitosan nanoparticles (CTS NPs) have been suscessfully combined with Carica papaya leaves (CPLs) extract for 30 min at room temperature. The prepared chitosan nanoparticles (CTS NPs)/Carica papaya leaves...
EXPRESSION OF TUMOR SUPPRESSOR GENE P53 CORRELATION WITH GASTRIC ADENOCARCINOMA PATIENTS BY USING IMMUNOHISTOCHEMICAL ASSAY
Over expression of P53, tumor suppressor gene and alternation may involved in many types of human cancers, one of the most important kind is gastric cancer. In the current study, we shed the light on the relation between...