Recent progress in therapeutic angiogenesis
Journal Title: International Journal of Biomedical Science (IJBS) - Year 2007, Vol 3, Issue 3
Abstract
Coronary artery disease and peripheral arterial disease are devastating status of acute vessel occlusion in diseased vessels that are already narrowed enough by atherosclerotic process. People are now focused on therapeutic angiogenesis against the ischemic diseases, to supply and growth of new vessels into the ischemic tissue. Recently, we and others performed autologous transplantation of bone marrow mononuclear cell or endothelial progenitor cell and gene therapy using hepatocyte growth factor (HGF) in clinical trials. Autologous implantation of bone marrow mononuclear cells or endothelial progenitor cells in ischemic limb or heart may induce blood flow and improve function in several pilot clinical studies. The regenerative potential of bone-marrow cells can be explained by any of four mechanisms, transdiffentiaion, cytokine-induced growth, stimulation of endogenous stem cells, and induction of cell fusion. Transdifferentiaion has been described by previous investigators and the concept has been called into question by recent experimental studies. In the pilot clinical study, similar improvements were seen in gene therapy using HGF in peripheral arterial diseases which might be more noninvasive. The clinical significance of the novel therapeutic approach might embrace the large number of patients with peripheral arterial diseases and with chronic coronary artery disease. And we need to figure out the strong angiogenic factor or specific differentiated progenitor cells for therapeutic angiogenesis in the study of bone marrow cell therapy. For the patients, we need to constitute a safe and effective strategy for achievement of therapeutic angiogenesis. How to cite this article: Int. J. Biomed. Sci. 2007; 3(3):153-158 For full text article or PDF file, visit: www.ijbs.org
Authors and Affiliations
Hironori Nakagami, Ryuichi Morishita
Keywords
Related Articles
- EP ID EP83999
- DOI -
- Views 104
- Downloads 0
TP53 codon 72 Gene Polymorphism Paradox in Associated with Various Carcinoma Incidences, Invasiveness and Chemotherapy Responses
TP53 is the most common mutated gene in human cancers. Approximately half of all human malignancies exhibit TP53 mutations. The TP53 codon 72 polymorphism is a single-nucleotide polymorphism (SNP) in exon 4, resulting in...
<br /> Dietary Supplementation of Vitamin E and α-lipoic Acid Upregulates Cell Growth and Signaling Genes in Rat Myocardium
The efficacy of antioxidant supplementation in the prevention of cardiovascular disease appears equivocal, however the use of more potent antioxidant combinations than those traditionally used may exert a more positive e...
An investigation on the solid dispersions of chlordiazepoxide
The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid...
Role of Genetic Changes in the Progression of Cardiovascular Diseases
This review aims to investigate the role of genetic changes in the development of cardiovascular diseases [CVD]. Oxidation of Low density Lipoprotein (LDL) and mutations in LDLreceptors gene are a trigger for numerous of...
Analysis of peptidases in non-infected and Trypanosoma cruzi-infected mouse embryo hepatocyte cells
Cellular peptidase profiles from non-infected and Trypanosoma cruzi-infected hepatocyte cell cultures were characterized by substrate-SDS-PAGE containing different copolymerized proteins. A 100-kDa metallopeptidase had...