Redox status in benign prostatic hyperplasia and non-metastatic prostate cancer in the Algerian population
Journal Title: UNKNOWN - Year 2017, Vol 1, Issue 2
Abstract
Background: Depletion of cellular antioxidants can result from free radical formation due to normal endogenous reactions and the ingestion of exogenous substances and environmental factors. The levels of reactive oxygen species (ROS) have been shown to be significantly altered in malignant cells and in primary cancer tissues. We undertook the present study to investigate the possible alteration of oxidant/antioxidant status in Algerian patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Methods: In total, 89 subjects made up of 26 patients with non-metastatic prostate cancer, 31 with benign prostatic hyperplasia (BPH), and 32 controls participated in this study. The concentrations of plasmatic malondialdehyde (MDA), erythrocytes catalase activity (CAT), and the plasma glutathione levels (GSH) were estimated using standard procedures. Results: The results showed that MDA concentrations were significantly increased while erythrocyte catalase activity was significantly decreased in the prostate cancer group versus controls (P < 0.01) and BPH group (P < 0.05). GSH levels were lowered in prostate cancer patients versus control group with no significant changes. Conclusions: Our results suggest that an alteration in the lipid peroxidation index with concomitant changes in the antioxidant defense system in prostate cancer patients compared with controls. We hypothesize that an altered pro-oxidant–antioxidant balance may lead to an increase in oxidative damage and consequently may play an important role in prostate carcinogenesis.
Authors and Affiliations
Rima Mouhoub, Karima Haddad, Sarah Goumeri, Raouf Oucherif, Bahia Djerdjouri, Malika Khelil
Keywords
Related Articles
- EP ID EP261236
- DOI 10.26415/2572-004X-vol1iss2p42-43
- Views 102
- Downloads 0
Modeling of the temperature field of a tumor tissue loaded by magnetic nanoparticles
Background: Magnetic hyperthermia is a recent therapy used to treat cancer. It is based on the heating of magnetic nanoparticles under the effect of an alternating magnetic field. A mathematical study was considered the...
The new design of a remote real time embedded medical platform
Background: The aim of this work is to develop an electronic medical platform that enables us to monitor the physiological data of a patient and allows in cases of urgent problems to trigger an alarm remotely controlled...
Technological advances: what hope for colorectal cancer?
Introduction: Colorectal cancers rank third in all cancers. Mass screening has proven effectiveness by significantly reducing incidence and mortality. If optical colonoscopy is the reference exam, virtual colonoscopy is...
Brain Structures Segmentation by using Statistical Models
Background: Automatic segmentation of brain structures is a fundamental step for quantitative analysis of images in many brain’s pathologies such as Alzheimer’s, brain’s tumors or multiple sclerosis. The goal of our work...
Telemedicine and e-health in Algeria facing challenges in medical practice
The Algerian health system operates in a demographic, economic, environmental, and societal specific context to meet the challenges of epidemiological transition. Development of information and communication technologies...