Reference range study in a neuron-specific enolase (NSE) assay
Journal Title: Journal of Analytical Bio-Science - Year 2011, Vol 34, Issue 5
Abstract
Neuron-specific enolase (NSE) is widely used as a marker of small-cell lung cancer. Upper reference range for total plasma NSE level in adults is usually 12.0 ng/mL, as arranged by the manufacturer of the measurement kit. However, in more than 30% of the medical checkup clients in our hospital a high NSE value was obsorved. To investigate its causes, we optimized preanalytical factors for measurement such as time before centrifugation, preserving time and temperature. A group of 315 apparently healthy subjects were enrolled for reference range study and we estimated the 95th percentiles for each analyte.
Authors and Affiliations
Taeko Hotta
Keywords
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