Reflux-Related Renal Injury (Reflux Nephropathy): Do Nonsteroidal Anti-Inflammatory Drugs (Ibuprofen) Increases’ the Risks?
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 12
Abstract
Reflux predisposes to facilitating the transport of bacteria from the bladder to the upper urinary tract and infection of the kidney by it. So the objectives of this study were to examine the influence of nonsteroidal anti-inflammatory drugs (Ibuprofen) in risk of reflux nephropathy. In this study we conducted a description of a case series (Children who had febrile UTI and treatment with ibuprofen 193(case group), and acetaminophen180 (control group)) in the pediatric clinic of Amirkabir hospital to characterize risk of Ibuprofen in a cohort study of patients with reflux nephropathy. The prevalence of reflux nephropathy was 4% in control group and 26% in case group. Based on chi-square test, the distribution of reflux nephropathy is difference in the two groups (p=0.0003). We concluded that there is apparent correlation between ibuprofen and reflux nephropathy. Keywords:Reflux Nephropathy, Ibuprofen, NSAID.
Authors and Affiliations
Parsa Yousefichaijan, MasoudRezagholi Zamenjany, Fatemeh Dorreh, Fakhreddin Shariatmadari, Yazdan Ghandi, Sara Khalighi
Keywords
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