RELATIONSHIP BETWEEN SERUM VITAMIN D LEVEL AND ANGIOGRAPHIC SEVERITY IN CORONARY ARTERY DISEASE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 22
Abstract
BACKGROUND The aim of the study is to study the correlation of plasma 25-hydroxy vitamin D level with angiographic severity (Gensini score1 ) in Coronary Artery Disease (CAD). To determine the relation between vitamin D levels and angiographic severity of CAD2,3,4 using Gensini score using patients with normal angiographic findings as controls. After appropriate consent, following measurement of vitamin D levels with ECLIA method in all subjects, coronary angiogram was done. Experimental data suggest that vitamin D levels influences thrombotic deficiency5,6 and endothelial dysfunction, 7 which plays an important role in CAD. The results of angiographic study and vitamin D were then analysed in a double-blinded fashion by a third party. MATERIALS AND METHODS Place of Study- Department of General Medicine and Cardiology of Andhra Medical College, Visakhapatnam, India. Type of Study- Prospective study. Period of Study- November 2015 to December 2016. This study was approved by the ethical committee of Andhra Medical College, Visakhapatnam, Andhra Pradesh State. RESULTS Our final results showed a trend towards increasing severity of CAD and LV dysfunction with progressive decrease in vitamin D levels, but unfortunately were not statistically significant. However, in a few subsets like elderly patients and diabetics, the values were significant. Further studies should be contemplated to determine exact role of vitamin D in atherosclerotic heart disease. CONCLUSION Our study showed that there is a trend towards increasing severity of CAD with decreasing levels of vitamin D in various subsets of patients with atherosclerosis. However, the results were not statistically significant, but the encouraging trend in our study should pave path for further studies to determine the optimal role of vitamin D in the pathogenesis and prognostication of patients with CAD.
Authors and Affiliations
Surya Prakasarao Salla, Rithesh Patchipala, Sailaja Paidi
Keywords
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- EP ID EP215242
- DOI 10.18410/jebmh/2017/246
- Views 93
- Downloads 0
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