Relationship between small for gestational age and aortic intima-media thickness in newborns
Journal Title: Paediatrica Indonesiana - Year 2014, Vol 54, Issue 1
Abstract
Background Small for gestational age (SGA) has been associatedwith adult cardiovascular disease. Small for gestational agenewborns may undergo early aortic wall intima-media thickening(aIMT) in utero.Objective To determine the relationship between SGA as a riskfactor for increased aIMT, as a sign of atherosclerosis onset.Methods We conducted a case-control study in the Neonatal Wardand Rooming-in Nursery at Dr. Mohammad Hoesin Hospital,Palembang, between April to June 2012. Subjects were allocatedto either the case group (aIMT 2: 0.9 mm) or to the controlgroup (aIMT <0.9 mm). Newborns were classified as SGA iftheir birthweight (BW) was < l O'h percentile, and appropriatefor gestational age (AGA) if their BW was between lQth - 90'hpercentile, according to the Lubchenco curve. Abdominal aorticintima-media thickness was measured by echocardiographyexamination.Results The case and control groups consisted of 30 n ewbornseach. The proportion of SGA newborns was higher in the casegroup than the control group. The likelihood of infants in the casegroup being SGA was significantly higher compared to the controlgroup, with odds ratio of 10.8 (95%CI 3,26 to 35, 72) . The meanaIMT was significantly higher in SGA than in AGA infants, 0.9(SD 0.16) mm vs. 0.8 (SD 0.13) mm, respectively, with a meandifference of 0, 13 (9 5% CI 0, 050 to 0,209 mm; P"" 0,02).Conclusion Increased aIMT is more likely found in SGA newborns.
Authors and Affiliations
Ahmad Alfarizi, Ria Nova, Julniar Tasli, Theodorus Theodorus
Keywords
Related Articles
- EP ID EP458700
- DOI 10.14238/pi54.1.2014.57-61
- Views 88
- Downloads 0
Relationship between children’s and parents’ blood pressure
Background A family history of hypertension is a risk factor forhypertension in children. Past studies have reported a significantrelationship between elevated blood pressure in children andhypertensive parents.Objective...
The outcomes of childhood acute lymphoblastic leukemia with hyperleukocytosis
Background Hyperleukocytosis in childhood acute lymphoblastic leukemia (ALL) is an emergency in oncology. This condition showed high mortality and relapse rates, as well as low survival rate. The outcomes of this g...
Electroencephalogram abnormalities in full term infants with history of severe asphyxia
Background An electroencephalogram (EEG) is an electroimaging tool used to determine developmental and electrical problems in the brain. A history of severe asphyxia is a risk factor for these brain problems in infants....
Focused group discussion with health care staff improves breastfeeding rates in hospitalized infants
Background Improving breastfeeding in sick infants is essential. During the neonatal care, health care staff play an important role in promoting breastfeeding. Therefore, it is important to study in depth how healthcare...
Maternal attitude and child interest in various play activities before and after mother-child play sessions
Background Play stimulates children’s growth and development. When mothers and their children play, a positive attitude from the mother and adequate interest from the child is required. Little is known about the play act...