Relationship between the level of prostaglandin E2 in tears and the severity of dry eye
Journal Title: Eye Science (Yanke Xuebao) - Year 2021, Vol 36, Issue 4
Abstract
[Objective:] To investigate the relationship between the level of prostaglandin E2 (PGE2) in tears and the severity of dry eye. [Methods:] Sixty patients with dry eye were selected and investigated with the Ocular Surface Disease Index (OSDI) questionnaire and ophthalmic examination, including tear film break-up time (BUT), corneal fluorescein staining score (CFLS) and tear secretion test (Schirmer I test). The level of PGE2 in tears was measured by enzyme-linked immunosorbent assay (ELISA). The relationship between the level of PGE2 in tears and related indexes of dry eye clinical symptoms was analyzed. [Results:] The average level of PGE2 in tears of patients with dry eye was (446.39±139.34) pg/mL. The level of PGE2 in tears of patients with dry eye was positively correlated with the OSDI score (r=0.458, P<0.001). PGE2 levels were not significantly correlated with BUT (r=0.164, P=0.354), Schirmer I score (r=−0.076, P=0.460), and CFLS score (r=0.265, P=0.086). Linear regression analysis showed that the level of PGE2 in tears was positively correlated with OSDI score (95% CI: 7.04–20.18, t=4.01, P<0.001). [Conclusion:] The level of PGE2 in tears is positively correlated with OSDI score, but has no significant correlation with BUT, the CFLS score and Schirmer I test.
Authors and Affiliations
Zhongfang ZHAO, Wenhui MA, Gaiping DU
Keywords
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- EP ID EP763498
- DOI 10.3978/j.issn.1000-4432.2021.01.13
- Views 23
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