Removal of serological interference in the treatment of multiple myeloma with CD38 monoclonal antibody using polybrene method
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 8
Abstract
Objective To investigate the clinical feasibility of polybrene method to remove serological interference in patients receiving anti-CD38 monoclonal antibody for the treatment of multiple myeloma, and its detection performance of alloantibodies. Methods For patients receiving anti-CD38 monoclonal antibody for the treatment of multiple myeloma, unexpected antibody screening and cross-matching blood test were performed by polybrene method. Results The polybrene method can remove the interference of anti-CD38 monoclonal antibodies on blood group serology; both methods can effectively remove anti-CD38 monoclonal antibody to detect anti-E, anti-D, anti-Fya and anti-S antibodies.The titers of anti-D, anti-E, anti-Fya and anti-S alloantibodies, yielded by enhanced polybrene method, were higher than those of the polybrene method.Seven patients received K-antigen-negative blood transfusion without any adverse reactions to blood transfusion. Conclusion For the treatment of multiple myeloma using CD38 monoclonal antibody, the polybrene method can quickly and effectively remove the interference of daratumumab with blood group serology.
Authors and Affiliations
Yan ZHENG, Wenting WANG, Shijie MU, Xia XIE, Qiong WANG
Keywords
Related Articles
- EP ID EP738329
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.08.022
- Views 54
- Downloads 0
Transfusion reactions in 711 pediatric patients: a retrospective analysis
Objective To analyze the characteristics and related influencing factors of transfusion reactions in pediatric patients, so as to provide evidence for clinical treatment and prevention of transfusion reactions. Methods A...
Serological and molecular biological characteristics of hepatitis B vaccinated donors with asymptomatic chronical infection in Shenzhen
Objective To investigate asymptomatic infection of hepatitis B virus(HBV) among hepatitis B vaccinated donors in Shenzhen, and analyze its serological and molecular characteristics. Methods The HBsAg ELISA positive blood...
Impact of blood screening strategies for Hepatitis C virus on blood safety
Objective To establish a reasonable and effective blood screening strategy for Hepatitis C virus (HCV), so as to reduce the risk of blood transfusion transmission, ensure blood safety and improve the quality of blood scr...
Application of machine learning in predictive analysis of blood usage for liver transplantation surgery
Objective To explore the application of machine learning in scientific and rational blood preparation and predictive analysis for surgical blood usage before liver transplantation surgery. Methods Clinical basic informat...
Establishment and evaluation of a competitive performance evaluation system for blood centers
Objective To investigate the establishment of a competitive performance evaluation management program for blood centers to ensure the blood supply. Methods A competitive performance evaluation system for Blood Donor Serv...