Research advances of noninvasive diagnosis of fibrotic non-alcoholic steatohepatitis
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
A subset of patients with non-alcoholic fatty liver disease （NAFLD） can progress to nonalcoholic steatohepatitis （NASH）. When NASH reaches a fibrosis degree of F≥2 and a NAS score of≥4， this stage of NASH is referred to as fibrotic NASH， which is a key focus in clinical drug trials. Currently， liver biopsy is the gold standard for assessing the histological changes of the liver， but its clinical application is limited by its invasiveness， and therefore， it is of particular importance to develop noninvasive detection methods for fibrotic NASH. This article summarizes the recent research achievements in novel noninvasive diagnostic methods for fibrotic NASH and elaborates on these new diagnostic methods for predicting fibrotic NASH in terms of current status， challenges faced， and prospects for future development.
Authors and Affiliations
Gong FENG, Rongyao KONG, Jiaxue WANG, Tianyue WU, Xiaohui WU, Juning WANG, Qinqin YAN, Man MI
Keywords
Related Articles
- EP ID EP753489
- DOI 10.12449/JCH241125
- Views 26
- Downloads 1
Establishment of a risk model based on immunogenic cell death-related genes and its value in predicting the prognosis and tumor microenvironment characteristics of hepatocellular carcinoma
[Objective] To identify immunogenic cell death （ICD）-related genes in hepatocellular carcinoma （HCC）， and to establish a scoring model based on these genes for predicting the prognosis and tumor microenvironment cha...
Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis
Hepatitis B virus （HBV） infection can cause acute or chronic infection， while untreated patients can develop into liver cirrhosis or liver cancer， thereby leading to death. As one of the most important organelles of...
Role of autophagy in treatment of paracetamol-induced liver injury
N-acetyl-p-aminophenol （APAP） is an antipyretic analgesic commonly used in clinical practice， and APAP overdose can cause severe liver injury and even death. In recent years， the incidence rate of APAP-induced liver...
Working practices in eliminating the public health crisis caused by viral hepatitis in Hainan Province of China
In 2022， Hainan provincial government launched the project for the prevention and control of viral hepatitis with the goals of a hepatitis B screening rate of 90%， a diagnostic rate of 90%， and a treatment rate of 80%...
Risk factors for the prognosis of elderly patients with hepatitis B virus-related acute-on-chronic liver failure and construction of a nomogram model for risk prediction
[Objective] To investigate the clinical features of elderly patients with hepatitis B virus-related acute-on-chronic liver failure （HBV-ACLF） and the risk factors affecting the short-term prognosis of patients. [Method...