Research on the mechanism of immune escape mediated by microenvironment in multiple myeloma
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 6
Abstract
Multiple myeloma (MM) is a malignant tumor of the hematological system caused by abnormal proliferation of plasma cells in bone marrow. The progression of the disease is strongly regulated by immunosuppressive tumor microenvironment (TME), which is beneficial to the spread of tumor cells. The survival of patients have been greatly improved with the clinical application of new drugs. At present, several T cell-based immunotherapies, such as bispecific antibodies, immune checkpoint inhibitors and chimeric antigen receptor T-cell immunotherapy (CAR-T), are successfully entering the field of immunotherapy with very promising results in clinical trials. However, similar to what has been observed in clinical chemotherapy, MM cells appear to be able to evade immunotherapy, especially through interaction with the bone marrow microenvironment. This paper summarizes the changes in cellular composition and related signaling pathways in bone marrow microenvironment during the disease progression, in order to explain the potential mechanism of immune escape of MM cells mediated by the bone marrow microenvironment.
Authors and Affiliations
HEI Xiaofei, LU Xuzhang
Keywords
Related Articles
- EP ID EP738474
- DOI 10.13429/j.cnki.cjcr.2024.06.028
- Views 38
- Downloads 0
Correlation of gut microbiota with serum inflammatory index and 25-hydroxyvitamm D level in malnourished children
Objective To investigate the status of intestinal flora in malnourished children and its relationship with se.rum inflammatory cytokines and 25.hydroxyvitamin D［25 (OH) D］levels. Methods A total of 126 malnourished chi...
Changes and significance of α kinase 1 expression in cartilage tisssueof patients with knee osteoarthritis
<b>Objective</b> To investigate the expression changes and significance of α kinase 1 （ALPK1）, a member of the α kinase family, in cartilage tissue of knee osteoarthritis （OA）. <b>Methods</b> Twenty-five patients...
Relationship between driver gene mutation status in non-small cell lung cancer and the incidence of venous thromboembolism: a Meta-analysis
Objective：To systematically review the incidence of venous thromboembolism (VTE) in patients with non-small-cell lung cancer (NSCLC) by different driver gene mutations, and to further explore the associations of driver...
Comparison of clinical efficacy between laparoscopic total gastrectomy and proximal gastrectomy in the treatment of adenocarcinoma of esophagogastric junction
<b>Objective</b> To compare the advantages and disadvantages of two different resection margins by observing the clinical efficacy of laparoscopic total gastrectomy (TG) and proximal gastrectomy(PG) for radical resection...
Clinical efficacy of ultrasound-guided acupotomy combined with joint mobilization surgery in treatment of frozen shoulder
<b>Objective</b> To observe the application and clinical efficacy of ultrasound-guided acupotomy combined with joint mobilization surgery in the treatment of frozen shoulder. <b>Methods</b> One hundred and twenty pat...