Research on the mechanism of immune escape mediated by microenvironment in multiple myeloma

Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 6

Abstract

Multiple myeloma (MM) is a malignant tumor of the hematological system caused by abnormal proliferation of plasma cells in bone marrow. The progression of the disease is strongly regulated by immunosuppressive tumor microenvironment (TME), which is beneficial to the spread of tumor cells. The survival of patients have been greatly improved with the clinical application of new drugs. At present, several T cell-based immunotherapies, such as bispecific antibodies, immune checkpoint inhibitors and chimeric antigen receptor T-cell immunotherapy (CAR-T), are successfully entering the field of immunotherapy with very promising results in clinical trials. However, similar to what has been observed in clinical chemotherapy, MM cells appear to be able to evade immunotherapy, especially through interaction with the bone marrow microenvironment. This paper summarizes the changes in cellular composition and related signaling pathways in bone marrow microenvironment during the disease progression, in order to explain the potential mechanism of immune escape of MM cells mediated by the bone marrow microenvironment.

Authors and Affiliations

HEI Xiaofei, LU Xuzhang

Keywords

Related Articles

Prognosis of 111 young patients with hypertensive intracerebral hemorrhage: a single center clinical study

<b>Objective</b> To explore the differences in prognosis of young hypertensive intracerebral hemorrhage (HIH) patients with different age, gender, and bleeding sites. <b>Methods</b> A retrospective analysis of 111 young...

Relationship between XRCC1 protein, miR-7, c-erbB-2 gene expression levels and radiotherapy resistance in non-small cell lung cancer

Objective To analyze the relationship between XRCC1 protein, miR-7, c-erbB-2 gene expression and radiotherapy resistance in non-small cell lung cancer (NSCLC) and their predictive value. Methods From January 2020 to Ju...

Application of high flow nasal cannula oxygen therapy in elderly patients with acute exacerbation of chronic obstructive pulmonary disease and type Ⅱ respiratory failure

<b>Objective</b> To investigate the therapeutic effect of high flow nasal cannula oxygen therapy (HFNC) on elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and type Ⅱ respiratory...

Predictive role of serum interleukin-37 on prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease

<b>Objective</b> To observe the changes of serum interleukin (IL)-37 levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its predictive role on prognosis. <b>Methods</b> A t...

Neuronavigation-guided percutaneous balloon compression for treatment of primary trigeminal neuralgia in elderly patients

Objective:To explore the clinical application effect of percutaneous balloon compression (PBC) under neuronavigation guidance for the precise treatment of trigeminal neuralgia in elderly patients. Methods:A retrospecti...

Download PDF file
  • EP ID EP738474
  • DOI 10.13429/j.cnki.cjcr.2024.06.028
  • Views 37
  • Downloads 0

How To Cite

HEI Xiaofei, LU Xuzhang (2024). Research on the mechanism of immune escape mediated by microenvironment in multiple myeloma. Chinese Journal of Clinical Research, 37(6), -. https://www.europub.co.uk/articles/-A-738474