Research progress in structural modification of Camptothecins
Journal Title: Biomedical Transformation - Year 2024, Vol 5, Issue 1
Abstract
Camptothecin and its derivatives are alkaloids with broad-spectrum anti-tumor activities and have significant inhibitory effect on malignant tumors. Its derivatives such as irinotecan and topotecan have been on market over 20 years. As a antitumor drug family, main problems of camptothecins are low solubility, poor structural stability, and strong toxic side effects, therefore the corresponding structural modification strategies are upgraded with the improvement of drug development. The author aims to improve the efficacy of camptothecin based anti-tumor drugs and reviews the development process of camptothecin and its derivatives from the perspective of structural modification strategies. The focus is on summarizing the latest progress in research on camptothecin based derivatives under various strategic guidance since 2015, providing reference for the development of new camptothecin based anti-tumor drugs in the future.
Authors and Affiliations
Sun Shulei, Liu Xinxin, Hu Zhiwei, Wang Ziming
Keywords
Related Articles
- EP ID EP766042
- DOI 10.12287/j.issn.2096-8965.20240106
- Views 20
- Downloads 0
Advances on the pharmacological activity and mechanism of saikosaponin A
Saikosaponin A (SSA) is specified as one of the labeled compounds for evaluating the quality of Bupleurum in the Pharmacopoeia of the People's Republic of China (the 2020 edition of the Chinese Pharmacopoeia Commission)....
Current status and challenges of lung transplantation in China
Lung transplantation (LTx) is the only effective treatment for patients with end-stage lung disease. The field of LTx has undergone tremendous progress over the past four decades in China. The domestic filed of LTx is in...
Treatment and prospects of patients with recurrent IVF failures caused by mutations
Infertility has become the third largest human disease in the world. With the wide application of in vitro fertilization (IVF), millions of people solve the problem of infertility by IVF every year. However, many patient...
Analysis of potential genes and immune infiltration related to astrocytoma
Objective To identify the core genes related to astrocytoma using bioinformatics. Methods Expression datasets GSE70231 and GSE138999 of astrocytoma were downloaded from the Gene Expression Omnibus (GEO) database and Diff...
New pathways and mechanisms of unexplained miscarriage induced by environmental pollutants
Environmental pollutants may be an important risk factor for unexplained miscarriage. Studies have shown that various environmental pollutants, such as polycyclic aromatic hydrocarbons, nanoplastics, metallic substances,...