Research progress in the treatment of chronic ocular graft-versus-host disease
Journal Title: Eye Science (Yanke Xuebao) - Year 2022, Vol 37, Issue 5
Abstract
More than half of the patients developed chronic graft-versus-host disease after accepting allogeneic hematopoietic stem cell transplantation suffer from ocular graft-versus-host disease. Ocular graft-versus-host disease involves persistent inflammation and fibrosis of the ocular surface and keratoconjunctivitis sicca is the most common symptom. Severe ocular graft-versus-host disease not only affects patients' life quality, but also increases the risk of other ocular complications. The treatment of chronic ocular graft-versus-host disease mainly includes drug treatment, such as local application of artificial tears, serum eye drops and anti-inflammatory drugs; physical treatment, such as wearing contact lenses and meibomian gland massage; surgical treatment, such as punctal occlusion and reconstructing ocular surface. With the in-depth study of the pathogenesis of ocular graft-versus-host disease, many new therapeutic drugs and methods have emerged. Summarizing the latest research progress in drug, physical and surgical therapy of chronic ocular graft-versus-host disease will give us insights into treatment options and hot spot of research.
Authors and Affiliations
Wanyi KE, Min ZHOU, Leqi CAI, Pengxia WAN
Keywords
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- EP ID EP763672
- DOI 10.3978/j.issn.1000-4432.2022.02.02
- Views 22
- Downloads 0
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