Research progress of exosomes in eye diseases
Journal Title: Eye Science (Yanke Xuebao) - Year 2023, Vol 38, Issue 6
Abstract
Exosomes are nanoscale vesicles with a diameter of 30 nm to 150 nm, which are composed of lipid bilayers, proteins, and genetic material. Almost all types of cells in the human body can secrete exosomes. They play key roles in cellular communication, immune regulation, inflammatory responses and neovascularization. At present, exosomes have been widely studied in tumors, cardiovascular and urinary systems. In recent years, the role of exosomes in eye diseases has attracted more and more attention. The exosomes play an important role in the occurrence and development of common eye diseases such as keratopathy, age-related macular disease, diabetic retinopathy, glaucoma, etc. Currently it is a hot topic that the therapeutic potential of extracellular vesicles derived from different mesenchymal stem cells in eye diseases. The exosomes derived from mesenchymal stem cells have anti-inflammatory, anti apoptotic, neuroprotective and tissue repairing effects, which are similar to those of mesenchymal stem cells. Thus, exosomes may be a novel direction of research in the treatment of many eye diseases without cell therapy. Further understanding of the biological characteristics of exosomes and the latest research progress of exosomes in common eye diseases will provide reference for the pathogenesis and prevention strategies of related eye diseases.
Authors and Affiliations
Jingjie HU, Xinyu LI
Keywords
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- DOI 10.12419/2212300001
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