Research progress on function of apolipoprotein A1 and its mimetic peptides and the relationship with retinal diseases
Journal Title: Eye Science (Yanke Xuebao) - Year 2020, Vol 35, Issue 6
Abstract
The pathogenesis of retinal diseases is complex, involving with oxidative stress, pathological angiogenesis and lipid deposition. Apolipoprotein A1 (apoA1) and its mimetic peptides have anti-inflammatory, antioxidant, reverse lipid transport and angiogenesis regulation functions. The safety and effectiveness of oral use of mimetic peptide D-4F have been confirmed in both animal and human studies. Therefore, D-4F is the most widely studied at present. In recent years, apoA1 and its mimetic peptides are closely related with diabetic retinopathy, age-related macular degeneration and other retinal diseases. In this article, the molecular structure, production and distribution, main physiological functions of apoA1 and its mimetic peptides, as well as the latest progress on the relationship with retinal diseases were reviewed.
Authors and Affiliations
Zhuting CHEN, Jie HU, Andina HU
Keywords
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- EP ID EP763452
- DOI 10.3978/j.issn.1000-4432.2020.12.01
- Views 25
- Downloads 0
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