Research progress on role of autophagy in traumatic optic neuropathy
Journal Title: Eye Science (Yanke Xuebao) - Year 2023, Vol 38, Issue 3
Abstract
Traumatic optic neuropathy is a blinding eye disease that causes severe damage to vision due to external force damage to the optic nerve.. Autophagy is an intracellular degradation pathway that helps maintain the balance between the synthesis of normal cell components and the breakdown of damaged organelles and toxic cellular components. Autophagy markers are increased in optic nerve and retina after optic nerve trauma. Autophagy may play different roles on retinal ganglion cells (RGCs) at different stages of traumatic optic neuropathy. Most studies have shown that upregulating autophagy can attenuate RGCs death in traumatic optic neuropathy; however, it has also been suggested that inhibition of autophagy at ultra-early stage after injury can inhibit RGCs axonal degeneration. In this review, we reviewed the definition and function of autophagy, the mechanism of autophagy, and summarized the change of autophagy level after optic nerve trauma, as well as the effects of autophagy in RGCs after optic nerve trauma.
Authors and Affiliations
Jiangying LIU, Kairui QIU, Xiaolai ZHOU, Liwen HE
Keywords
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- EP ID EP764628
- DOI 10.12419/j.issn.1000-4432.2023.03.11
- Views 19
- Downloads 0
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