Research status and advances in immunotherapy for chronic myeloid leukemia
Journal Title: Chinese Journal of Blood Transfusion - Year 2025, Vol 38, Issue 5
Abstract
Chronic myeloid leukemia (CML) is a malignant hematologic disorder caused by abnormal proliferation of hematopoietic stem cells. In recent years, while the application of tyrosine kinase inhibitors (TKIs) has significantly improved the prognosis of CML patients through in-depth exploration of pathogenesis of CML and advancements in targeted therapies, some patients still face challenges including drug resistance, disease relapse, and failure to achieve treatment-free remission. Imunotherapy, as a complementary or alternative strategy, holds significant potential for overcoming these limitations, and has gradually emerged as a critical research focus in CML treatment. This review aims to summarize the current research status and latest advances in immunotherapy for CML.
Authors and Affiliations
Mengmeng WANG, Jingyun MA, Boyu XIONG, Zhuowen DAI, Yueyue PAN, Qiong WANG
Keywords
Related Articles
- EP ID EP767966
- DOI 10.13303/j.cjbt.issn.1004-549x.2025.05.022
- Views 10
- Downloads 0
Establishment of a multi-rule quality control mechanism for blood nucleic acid screening results based on Poisson distribution
Objective To establish a quality control mechanism based on the Poisson distribution for monitoring contamination in nucleic acid testing (NAT) laboratories. Methods The study collected NAT single-reactivity rates and di...
Analysis of donation related vasovagal reactions in Hefei
Objective To explore the influencing factors and characteristics of blood donation-related vasovagal reactions in whole blood donation in Hefei city, and to put forward specific prevention measures. Methods Whole blood d...
Research progress of platelets and their derivatives based drug delivery systems
Platelets play an important role in physiological and pathological activities such as thrombosis, inflammation and tumorigenesis. At present, the application of platelets in drug delivery systems is increasingly studied....
Progress in plasma exchange for severe immune-related dermatoses
Plasma exchange (PE) is effective in a part of autoimmune diseases, and its main action mechanisms include removing pathogenic factors from the patient's blood, regulating immune function, replenishing normal plasma comp...
Factors influencing hemolysis rate of leukocyte-reduced red blood cells at the end of preservation period in blood donors
Objective To compare the current standards and explore the influencing factors for hemolysis rate of leukocyte-reduced red blood cells at the end of the preservation period, in order to formulate reasonable internal cont...