Resistance of Pseudomonas aeruginosa to antibiotics

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0

Abstract

The main problem in the treatment of nosocomial infections is the increasing drug resistance of microorganisms that cause them, limiting the number of effective antibiotics. Pseudomonas aeruginosa bacilli are the cause of many serious hospital-acquired infections occurring primarily in patients within high-risk groups. The most vulnerable are those with weakened immune systems, as well as those with extensive surgical wounds and burn wounds. Infections are usually of the nature of secondary infections, caused by multidrug strains. Due to the high antimicrobial activity, beta-lactams, aminoglycosides and quinolones are drugs commonly used in hospitals, both in prevention and treatment of infections with P. aeruginosa. However, their irrational use is associated with selection and spread of strains resistant to these antibiotics. Resistance of P. aeruginosa to antibiotics is the result of a number of independent co-occurring mechanisms. These are: reducing the membrane permeability, the efflux system, and production of enzymes inactivating and degrading antibiotics. The paper devotes special attention to the determination of resistance mechanisms responsible for this phenomenon.

Authors and Affiliations

Katarzyna Wolska, Barbara Kot, Małgorzata Piechota, Aneta Frankowska

Keywords

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  • EP ID EP67234
  • DOI -
  • Views 158
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How To Cite

Katarzyna Wolska, Barbara Kot, Małgorzata Piechota, Aneta Frankowska (2013). Resistance of Pseudomonas aeruginosa to antibiotics. Advances in Hygiene and Experimental Medicine, 67(0), 1300-1311. https://www.europub.co.uk/articles/-A-67234