RESPONSE OF HAART (HIGHLY ACTIVE ANTIRETROVIRAL THERAPY) ON CD4 COUNTS AND HAEMOGLOBIN IN PATIENTS WHO ACQUIRED HIV INFECTION BY HETEROSEXUAL AND BLOOD TRANSFUSION ROUTES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 53
Abstract
BACKGROUND Dynamics of HIV acquired through the blood transfusion is studied largely, there are no studies that show the difference of impact of HAART on HIV acquired by heterosexual and blood transfusion routes. This study compares the impact of HAART between these groups. MATERIALS AND METHODS It is a descriptive comparative study. Data of HIV patients was collected from records and observed for eight years period. 39 PLHA who acquired HIV by blood transfusion and were alive on HAART as on December 2012 were matched with 39 patients who acquired HIV by heterosexual route with age, sex and duration of ART were analysed. Data was analysed with CD4 raise and HB raise in both groups. RESULTS Total cases were 78. 39 patients who acquired HIV by transfusion and heterosexual route in each group were selected. 23 males and 16 females acquired HIV by transfusion route. 24 males and 15 females acquired HIV by heterosexual route. Mean age of both groups is 32.06 years. Mean duration of ART was 6.6 years for both groups. The mean raise in CD4 between two groups heterosexual and blood-transfusion was 440 and 544 respectively. The mean raise in HB between two groups heterosexual and blood-transfusion was 1.6 gms% and 2.6 gms% respectively. The CD4 raise was 20% more in transfusion-acquired HIV without statistical significance. The haemoglobin raise in transfusion-acquired HIV was 60% more than without statistical significance. Unpaired t-tests show females in transfusion group have statistically significant raise in HB. Unpaired t-tests show males in heterosexual group have statistically significant poor raise in CD4. CONCLUSION Response to HAART by patients who acquired HIV by blood transfusion was better than the patients who acquired HIV by heterosexual route. Differences in early stages of acute HIV infection and the differences in involvement of lymphatic tissues and reservoirs in transfusion-acquired HIV may be the reasons for better response to HAART
Authors and Affiliations
Ravichandran Narayanan, Raja Krishnaraj, Kumar Satagopan, Vijila S, AmalaSharmila Irudayaraj
Keywords
Related Articles
- EP ID EP220285
- DOI 10.14260/Jemds/2017/870
- Views 99
- Downloads 0
ENTEROCUTANEOUS FISTULA – A CASE REPORT
Enterocutaneous fistulas most commonly develop as a post operative complication of bowel surgery, though in 15% to 20% of cases fistulas occur spontaneously. Development is more frequent after emergency surgery...
A COMPARATIVE EVALUATION OF KETAMINE-PROPOFOL VERSUS FENTANYL-PROPOFOL IN TOTAL INTRAVENOUS ANAESTHESIA- A DOUBLE BLIND RANDOMISED CLINICAL TRIAL
BACKGROUND Propofol has emerged as a gold-standard for total intravenous anaesthesia (TIVA) for short surgical interventions but lack of analgesia remains its main shortcoming, therefore it is always combined with an ana...
EPITHELIOID TROPHOBLASTIC TUMOUR: A RARE CASE WITH AN UNUSUAL PRESENTATION
Here in we report a rare case of epithelioid trophoblastic tumour with a rare clinical presentation. Commonly, ETT presents with abnormal vaginal bleeding or lung metastases. Our case was a 22-year-old lady, Par...
COMPLETE UTERINE INVERSION DURING LOWER SEGMENT CAESAREAN SECTION
PRESENTATION OF CASE We describe a case of acute uterine inversion that occurred during a lower uterine segment caesarean section in a 20- year-old primigravida under subarachnoid block that was managed successfully. Dur...
COMPARISON OF CLINICAL PRESENTATION AND RISK FACTORS OF STROKE IN DIABETIC VERSUS NON-DIABETIC POPULATION- RESULTS OF A SINGLE CENTRE STUDY
BACKGROUND Objective- To compare clinical presentation and risk factors for the development of stroke in diabetics and non-diabetics population. MATERIALS AND METHODS In this comparative, descriptive study, adult diabeti...