Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation
Journal Title: Gulhane Medical Journal - Year 2020, Vol 62, Issue 4
Abstract
Aims: Medulloblastoma is very rare and accounts for only 1% of intracranial tumors in adults. There are limited treatment options for adult medulloblastoma patients who have relapsed or refractory disease. We aimed to show real-life data on health outcomes in adult patients with recurrent or refractory medulloblastoma patients who received autologous hematopoietic stem cell transplantation (AHSCT). Methods: We analyzed the data of 15 patients who underwent AHSCT after ifosfamide, carboplatin, and etoposide (ICE) as high-dose chemotherapy (HDCT) regimen for relapsed or refractory medulloblastoma from 2010 to 2020. Overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated. Results: Fifteen patients were observed in this study. The mean age of the study group was 27.9±8.1 years and 53.3% of the patients were female (n=8). ORR was 100%. The median OS and PFS were 24 months [95% confidence interval (CI): 11.4-36.5] and 13 months (95% CI: 10.2-15.8), respectively. One-year OS and PFS rates were 77% and 55.2%, respectively. Five-year OS rate was 82.5%. Conclusions: AHSCT with ICE as HDCT regimen is a safe and effective treatment option for relapsed or refractory adult medulloblastoma patients with an acceptable ORR, OS and PFS time.
Authors and Affiliations
Ramazan Acar, İsmail Ertürk, Halil Kızılöz, Sezgin Okçelik, Birol Yıldız, Musa Barış Aykan, Gül Sema Yıldıran Keskin, Erdim Sertoğlu, Bilgin Bahadır Başgöz, Nuri Karadurmuş
Keywords
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- EP ID EP691783
- DOI 10.4274/gulhane.galenos.2020.1180
- Views 135
- Downloads 0
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