RETROSPECTIVE STUDY OF COMPARATIVE EFFECTIVENESS OF TWO ARTESUNATE COMBINATION DRUG REGIMENS IN UNCOMPLICATED FALCIPARUM MALARIA IN CHILDREN
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 8
Abstract
Background: Malaria is a major cause of morbidity and mortality in children in developing world. Successful treatment and avoidance of resistance development to anti-malarial drugs in endemic areas are important current concern. Method: Medical records of children under 14 year age treated for uncomplicated falciparum malaria with artesunate combination regimens were reviewed. Comparative efficacy of two artesunate combinations either with amodiaquin or sulfodoxime-pyrimethamine was evaluated. Fever clearance time, parasite clearance time and length of hospital stay were the studied parameters. Result and Conclusion: Study on modest sample of 55 cases, 34 treated with artesunate-amodiaquine (AS-AQ) and 21 cases treated with artesunate-sulfodoxime-pyrimethamine (AS-SP) regimens revealed both to be effective. AS-AQ regimen appeared to be superior to AS-SP regimen in regard to faster parasite clearance and shorter hospital stay.
Authors and Affiliations
Anita Mehta, Abha Pandit
Keywords
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