Reversible Alteration of Blink Reflex in Hypothyroid Patients in Response to Treatment
Journal Title: International Journal of Current Research and Review - Year 2017, Vol 9, Issue 5
Abstract
Background: Hypothyroidism is associated with central and peripheral nervous system disturbances. It affects the CNS due to the impairment of the sensory pathways secondary to hormonal imbalances causing segmental demyelination. It also affects the transmission of impulses along the complex polysynaptic pathways, such as those mediating the blink reflex. Objective: Evaluation of Blink Reflex for early diagnosis of neurological dysfunction in hypothyroid patients and to study the response to treatment. Method: Blink Reflex was recorded using RMS EMG EP MK2 machine in 30 overt hypothyroid patients (serum TSH ≥10 mIU/L) between 18 – 50 years of age who were followed up after 3 months of treatment. Result: The latency of blink reflex showed an early ipsilateral R1 response and late R2 responses (ipsilateral R2i, contralateral R2c) which were found to be prolonged in the patients. Following the hormonal replacement therapy the latency tend to decrease while the amplitude was increased. Conclusion: Increased latency of blink reflex indicates impairment predominantly of the sensory pathways. These changes are further more altered in untreated patients in the advanced stage of the disease. Hence blink reflex is useful non-invasive tool for early detection of cranial neuropathy in newly diagnosed hypothyroid patients and to access their response to treatment.
Authors and Affiliations
Sharma G.
Keywords
Related Articles
- EP ID EP602490
- DOI -
- Views 131
- Downloads 0
Chlorpyrifos Impairs the Contraction of Uterine Smooth Muscle by Inhibiting the Secretion of Estradiol from Ovary in Rat
Objectives: Chlorpyrifos (CPF) has been used heedlessly in India to protect crop plants from pest induced crop loss. The objective of the study was to examine the effect of CPF, a broad spectrum organophosphate pesticide...
Effects of Brownian Motion and Thermophoresis on Magneto Hydrodynamics Stagnation Point of a Nanofluid Boundary Layer Flow on a Stretching Surface with Variable Thickness
The paper aims to investigate the properties of Brownian motion and Thermophoresis magento hydro dynamics (MHD) stagnation point of a Nanofluid Boundary layer flow on a stretching surface with inconsistent thickness. The...
Correlation between the Type of Arterial Vascularizacion and Presence and Localization of Myocardial Bridges
Introduction: Myocardial bridges represent an anomaly of the coronary arteries’ flow, which can be asymptomatic, or can lead to the coronary insufficiency and its clinical consequences. The aim of this research was to de...
Health and Policy Environment of Internal Labour Migrants in India – A Literature Review and Future Direction
Designing and implementing equitable health policies requires greater participation from the all groups of stakeholders. However, disadvantaged groups are under-represented in Indian policy making fora. Internal labour m...
A Comparative Study of Isolation of Obligate Anaerobes and Facultative Anaerobes in Microbial Flora of Non- Vital Teeth in Diabetic (Type II) and Non-Diabetic Patients
Introduction: The aim of the study was to evaluate and compare the anaerobic microflora (obligate and facultative) of the root canals of non vital teeth with periapical lesions, in diabetic (Type II) and non-diabetic pat...