RHEUMATOID ARTHRITIS AFFECTS BRAINSTEM AUDITORY EVOKED POTENTIAL
Journal Title: International Journal of Basic and Applied Physiology - Year 2015, Vol 4, Issue 1
Abstract
Background: Rheumatoid arthritis is a chronic multisystem disease characterized by persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution. Despite its predominant osteoarticular and periarticular manifestations, RA is a systemic disease often associated with cutaneous and organ-specific extra-articular manifestations. It has been seen that as many as 40% of patients may have extraarticular manifestations. It usually presents as polyarthritis affecting small or large joints. Brainstem auditory evoked potential recording can represent an objective, clinically useful and non-invasive procedure to stress the early impairment of both auditory nerves and brainstem function. Aims and Objectives: To study brainstem auditory evoked potential changes in rheumatoid arthritis patients Material and Method: Control (group 1) comprised of 25 healthy female subjects of age 30 to 50 years while study group (group 2) comprised of 25 female patients with RA of more than 5 years. Proven cases of RA (as per 1987 ACR criteria) underwent brainstem auditory evoked potentials. The recording was carried out by using RMS EMG EPMK2. Ear discharge, deafness, history of intake of ototoxic drugs, chronic hepatic, renal and respiratory diseases were excluded. Result: In left ear, the difference in absolute peak latency of wave IV of group 1 and 2 and the difference of wave V of group 1 and 2 were significant (p<0.05) while for rest of the waves it was insignificant (p>0.05). The differences in interpeak latencies (I-III, III-V, I-V) were insignificant (p>0.05). The difference in amplitude of I-Ia between group 1 and 2 was significant (p<0.05) but difference in amplitude of I-Va was insignificant (p>0.05). In right ear, difference in absolute peak latency of wave III of group 1 and 2 was significant (p<0.05) while for rest of the waves it was insignificant (p>0.05). The differences in interpeak latencies and amplitude were insignificant (p>0.05). Conclusion: Differences of absolute peak latency of wave IV and V in left ear and III in right ear were significant (p<0.05) when compared with control. The difference in amplitude of I-Ia was significant (p<0.05) in left ear when compared with control. Thus rheumatoid arthritis affects brainstem auditory evoked potential.
Authors and Affiliations
Shelja Deswal, Jyoti Yadav, Joginder Gulia, Harpreet Singh, Ashish Arvind
Keywords
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