Role of alkaloid compounds in regulating chronic liver diseases
Journal Title: Journal of Clinical Hepatology - Year 2025, Vol 41, Issue 2
Abstract
Chronic liver diseases with common causes including viral infections， alcohol abuse， and autoimmune diseases. Alkaloids， as a class of plant-derived compounds， have shown significant potential in regulating chronic liver diseases. Recent studies have shown that alkaloids are able to exert a therapeutic effect on chronic liver diseases through multiple pathways. These compounds have a regulatory effect on key pathological processes such as liver fibrosis， inflammatory response， oxidative stress， and cell apoptosis， and they also regulate the metabolic homeostasis of hepatocytes by modulating multiple signaling pathways， thereby playing a role in regulating chronic liver diseases. This article reviews the role and mechanism of alkaloids in the treatment of chronic liver diseases， in order to provide new ideas and directions for the treatment of chronic liver diseases.
Authors and Affiliations
Yihui ZHENG, Jiahui WANG, Tiejian ZHAO, Xuelin DUAN, Lei WANG, Yang ZHENG, Shiquan YANG
Keywords
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