Role of alteration in Treg/Th17 cells' balance in nephropathic patients with Type 2 diabetes mellitus.
Journal Title: Electronic Physician - Year 2015, Vol 7, Issue 8
Abstract
In type 2 diabetes mellitus, the adaptive immune system drives systemic inflammation, promoting insulin resistance and related complications, such as diabetic nephropathy. Increased infiltration of activated T lymphocytes has been found in patients with diabetic nephropathy. T-cell influx and accumulation are the factors that aggravate diabetic nephropathy and link with glomerular filtration surface and albumin excretion. An appropriate balance between pro-inflammatory (T helper 17: Th17, and T helper 1: Th1) and anti-inflammatory (regulatory T cells: Tregs) subsets of T cells is critical to maintain homeostasis and avoid inflammatory disease. The aim of this study was to determine the balance between T helper 17 and regulatory T cells in type 2 diabetic patients who have diabetic nephropathy.
Authors and Affiliations
Sameh Abouzeid, Nevine Sherif
Keywords
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- DOI 10.19082/1613
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