Role of amino acid metabolism in autoimmune hepatitis and related therapeutic targets
Journal Title: Journal of Clinical Hepatology - Year 2025, Vol 41, Issue 3
Abstract
Autoimmune hepatitis （AIH） is a chronic inflammatory liver disease. The pathogenesis of AIH remains unclear， but it is mainly autoimmune injury caused by the breakdown of autoimmune tolerance due to the abnormal activation of the immune system， while the specific molecular mechanism remains unknown. Recent studies have shown that abnormal amino acid metabolism plays an important role in the development and progression of AIH. This article reviews the research advances in amino acid metabolic reprogramming in AIH， in order to provide a theoretical basis for amino acid metabolism as a new target for the clinical diagnosis and treatment of AIH.
Authors and Affiliations
Peipei GUO, Yang XU, Jiaqi SHI, Yang WU, Lixia LU, Bin LI, Xiaohui YU
Keywords
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- EP ID EP768459
- DOI 10.12449/JCH250323
- Views 6
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