Role of Anti-Hepatitis C Virus (HCV) Signal to Cut-off Ratio (S/CO) in Following- up Patients Received Anti-HCV Therapy in Egypt
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 2
Abstract
<span>Background: </span><span>Hepatitis C Virus (HCV) infection is diagnosed by antibody and RNA based methods. Anti HCV-RNA testing based methods are introduced to confirm viremia in seropositive samples. This study aimed to evaluate the relationship between quantitative anti-HCV (S/CO ratio) and HCV-RNA by PCR as a diagnostic test to identify viremic from non-viremic HCV patients received anti-HCV therapy in Egypt. </span><span>Subjects and Methods: </span><span>Patients serum samples used in this study were collected from Al Hussein University hospitals after they had completed their anti-HCV therapy. A total of 172 patients were included in this study 82 were positive RNA, 90 of them were negative RNA their serum samples were assessed for the presence of antibodies to HCV using ELISA method. </span><span>Results: </span><span>The results were expressed as the ratio between the signal detected on the sample and the cutoff value of the run (S/CO). Patients with HCV-positive RNA were considered viremic. Receiver operator characteristic (ROC) curve was constructed by plotting sensitivity </span><span>versus 1 − specificity, using HCV RNA and the S/CO ratio results respectively. Of the 172 patients with HCV </span><span>infection the mean age was 51.9 ± 7.2 years ranging 35-67 years, 111 (64.5%) were males while 61(35.5%) were females. In the present study there was significant difference in S/CO ratio between viremic and non- viremic subjects. The sensitivity, specificity, negative predictive value, and positive predictive value were 98.78%, 71.11%, 98.46%, and 75.70%, respectively in the S/CO ratio of 8. Area under ROC curve was estimated to be 0.982 (95% confidence interval 0.967 </span><span>– </span><span>0.997). </span><span>Conclusion: </span><span>by establishing 8 as cutoff value of the S/CO, it is possible to distinguish between viremic and non-viremic patients without need to use Anti HCV-RNA testing as a confirmatory test.<br /> </span>
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584079
- DOI 10.21608/ejhm.2018.9094
- Views 117
- Downloads 0
Role of Electrocardiogram-Gated Multidetector Computed Tomography in Diagnosis of Congenital Heart Disease
Aim of the work: this study aimed to assess the role of ECG gated multidetector computed tomography in detection and characterization of congenital heart diseases. Patients and method: this study was carried out in the R...
A Comparison between Volume-Controlled Ventilation and Pressure-Controlled Ventilation in Providing Better Oxygenation in Obese Patients Undergoing Laparoscopic Cholecystectomy
Background: The main goal of mechanical ventilation is the maintenance of adequate oxygenation and ventilation. There is no guidelines on the mechanical ventilation in obese patients. This study aims to compare the effec...
Evaluation of knowledge, attitudes and practice of coronary artery disease risk factors among general population in Tabuk City, Saudi Arabia
Background: The prevalence of the coronary artery disease (CAD) is increasing in the developing countries, including Saudi Arabia. The aim of this study was to evaluate knowledge of CAD risk factors and to appraise the r...
Maternal Serum Vascular Endothelial Growth Factor in Patients with Preeclampsia
Background: Vascular endothelial growth factor and placental growth factor levels were significantly lower in patients of sever or early onset (34 weeks or less gestational age at onset of PET) pre-eclampsia than in cont...
Etiologies and Management of Postural Tachycardia Syndrome in Children
Postural tachycardia syndrome (POTS) is a chronic condition with frequent symptoms of orthostatic intolerance or with sympathetic activation and excessive tachycardia while standing, without significant hypotension. T...