Role of chromium compounds in diabetes
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 1
Abstract
Diabetes Mellitus is a complex disease where the carbohydrate, protein and fat metabolism is deranged and co-exists with insulin resistance. The defect is either in the secretion of insulin, in the insulin receptors or post receptor events1. It manifests as hyperglycemic state with dyslipidemia and other metabolic defects. Insulin promotes glucose uptake through its receptor located in the cell surface by generating signal that results in the translocation of glucose transporter (GLUT) to cell surface. Thereafter, glucose is transported to the cytoplasm through these receptors by facilitated diffusion in the muscle cell and the adipose tissues. In type 2 DM, the muscle cells and adipose tissues are resistant to this signaling pathway2-7. Trivalent chromium (Cr) vital micronutrient obtained from diet which serves to potentiate insulin action and maintenance of normal glucose tolerance. Studies suggest, chromium is an essential cofactor that is required for optimum insulin activity9-11. Cr increases insulin receptor numbers8 on cell surface of the target cells hence facilitates more insulin-receptor binding. Trivalent Cr, especially Cr tri-picolinate and chromium histidinate are effective in insulin resistance. Chromium replacement is essential in deficient conditions and this fact has been well established, the aim of this review is to assess the role of chromium in the pathology of diabetes.
Authors and Affiliations
Anisha Prasad
Keywords
Related Articles
- EP ID EP240432
- DOI -
- Views 135
- Downloads 0
Retrospective analysis on adverse drug reactions prevalence in the female population of Tertiary Care Hospital
Introduction Adverse drug reactions seems to be a major problem in women than menObjective This study as planned to assess the incidence rate clinical manifestations and causative agents for adverse drug reactions ADRs i...
Aluminium chloride catalyzed one-pot synthesis of 2-aryl substituted benzimidazoles and their antibacterial activity
2-aryl substituted benzimidazole derivatives were synthesized by using various aromatic aldehydes contains electron releasing as well as electron withdrawing groups, o-phenylenediamine and aluminium chloride as a catalys...
Drug utilization study in antenatal clinic of Obstetrics Gynaecology Department of a Tertiary Care Hospital attached with Medical College
Background: The principal aim of drug utilization research is to facilitate the rational use of drugs in populations. Pregnancy is a special physiological condition. Careful consideration of the benefit to the mother and...
Perception and practices of self medication of antibiotics among undergraduate students of a medical college
Background: the study was conducted to analyze the perceptions regarding self medication of antibiotics among medical students and to determine the practice of antibiotic self-medication among medical students. Methods:...
Pattern of availability of non-prescribed medicines and their use as self-medication in Gujarat: a house hold survey
Selfmedication is widely practiced everywhere in the world The drug for self medication has proven efficacy and safety for shortterm use in minor illnesses but there is the potential for misuse and abuse of themA cross s...