Role of Dexmedetomidine as Premedicant to Attenuate Pressor Response to Laryngoscopy and Intubation
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 10
Abstract
Aims and Objectives: To study the efficacy of intravenous dexmedetomidine in the dose of1mcg/kg as a premedication for attenuation of pressor response to laryngoscopy for endotracheal intubation, and dose requirements of anesthetics for induction. Method: Total 60 patients of either sex, ASA grade I, having age between 18-60 years, posted for elective surgery under general anaesthesia requiring endotracheal intubation were randomly allocated in two equal groups. Group A (Dexmedetomidine group)received Inj. dexmedetomidine 1 mcg/kg IV in 100ml of NS given over a period of 10 min in infusion form at constant rate prior to induction. Group B (placebo group) received 100ml of NS over a period of 10 min at constant rate prior to induction. All patients were monitored intra and postoperatively with respect to hemodynamic parameters, rate pressure product and any other side effects. Results: Group A significantly attenuated the sympathetic response to laryngoscopy and tracheal intubation in terms of heart rate, systolic and diastolic blood pressure, mean arterial pressure and rate pressure product compared to group B. The total dose of propofol for induction of general anesthesia was significantly less in group A as compared to group B. In both the groups, no patient had bradycardia or hypotension. Conclusion: Intravenous dexmedetomidine used as a premedication in a dose of 1 mcg/kg effectively blunted the pressor response to laryngoscopy and endotracheal intubation without any side effect.
Authors and Affiliations
Dr. Archana Vaidya
Keywords
Related Articles
- EP ID EP379146
- DOI -
- Views 122
- Downloads 0
A Pre-Experimental Study to Assess the Effectiveness of Planned Teaching Programme on Knowledge and Attitude Regarding Prevention of Obesity among Adolescent Girls in Selected Schools of Joginder Nagar, Mandi District, Himachal Pradesh
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems. An evaluatory appro...
Efficacy of Scaphoid Mobilization on Pain, Physical Function and Kinesiophobia in Patients with Lateral Epicondylitis
Background: Lateral epicondylitis is musculoskeletal condition involves the origin of extensor carpi radials brevis, leading to pain on resisted wrist extension. The regional interdependence model focuses on impairments...
Carbapenem Resistant Mechanism in Carbapenem Resistant Gram Negative Bacilli Other Than Carbapenemase
Introduction - Infections have been the major cause of disease throughout the history of human population. In the middle of the nineteenth century antibiotics are discovered as a powerful weapon in the battle against inf...
Phantom Hernia Due to Abdominal Herpes Zoster
Most of the complications of herpes zoster are sensory. Segmental motor weakness is an unusual complication. We present a case of 50 years old male who presented with phantom hernia 3 weeks after the appearance of herpes...
Synthesis of Silver Nanoparticle from Saraca Asoca Leaf Extract & Study of Its Antibacterial and Antioxidant Activity
The field of biotechnology has crossed yet another milestone with development of advanced stream as Nanotechnology. With huge potential of nanotechnology the human race can make immense profit and benefits in his life. O...