Role of High Dose Methylprednisolone in Children With Steroid Resistant Nephrotic Syndrome

Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11

Abstract

Treatment of Steroid Resistant Nephrotic Syndrome(SRNS) imposes one of the most difficult problems on nephrologists. IntraVenous Methyl Prednisolone(IVMP) is considered as one of the treatments of choice for children with oral steroid resistant Nephrotic Syndrome. We reviewed the clinical outcome in children with SRNS not responding to Tacrolimus under intravenous methyl prednisolone treatment. A total of 32 children presented with SRNS during the period from January 2011 to December 2017. Mean age of patients was 7.9 (Range- 4 to 9 years). Renal Biopsy was done in 12 out of 32 children which showed Focal Segmental Glomerulosclerosis (FSGS) in 8 patients, 2 patients had Minimal Change Disease (MCD), another 2 had Diffuse Mesangial Proliferation (DMP). Treatment with IVMP along with oral prednisolone induced remission in 12 patients (37.5%), 4 patients had complete remission and 8 patients had partial remission. We conclude, the study shows that IV Methyl Prednisolone can be tried in patients not responding to Calcineurin inhibitors in SRNS patients.

Authors and Affiliations

DrP. Arun Prasath, DrR. Arul, DrA. Jegan, DrJ. Prem Giovanni, Dr. P. Krishnananth

Keywords

Related Articles

Assessing Different Imaging Modalities for the Diagnosis of MayThurner Syndrome: A Review

May-Thurner Syndrome(MTS) is a type of venous compression syndrome typically characterized by the compression of left common iliac vein by the overlying right common iliac artery and the fifth lumbar vertebra causing ven...

Reteroperitoneal Abscess: A Rare Presentation of Duodenal Perforation.

Introduction: Long standing duodenal perforation presenting as retroperitoneal abscess. Case Report: We report a case of 60 year old female of sealed duodenal perforation presenting as retroperitoneal abscess. CECT abdom...

A study on the Knowledge, Attitude & Practice of Antibiotic usage and resistance among Under graduate medical students in a rural medical college – questionnaire based study

Antibiotic resistance (ABR) is considered to be a type of drug resistance where some or all populations of a bacterial species survive after exposure to antibiotics. 1 Antibiotics are the most frequently prescribed drugs...

Alternative approach for preservation of hopeless mandibular molar through hemisection with its different restorative modalities: a case series…..

Introduction : Hemisection of a mandibular molar is a treatment modality when the decay is constrained to one root and the other root is healthy. In this, a mandibular molar is sectioned into two halves followed by remov...

Download PDF file
  • EP ID EP409194
  • DOI 10.9790/0853-1711035557.
  • Views 90
  • Downloads 0

How To Cite

DrP. Arun Prasath, DrR. Arul, DrA. Jegan, DrJ. Prem Giovanni, Dr. P. Krishnananth (2018). Role of High Dose Methylprednisolone in Children With Steroid Resistant Nephrotic Syndrome. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 17(11), 55-57. https://www.europub.co.uk/articles/-A-409194