ROLE OF IDH1 MUTATION BY R 132 H ANTIBODY CLONE H09 IN GRADE II & III GLIOMAS AND SECONDARY GLIOBLASTOMA (As per current classification of CNS Tumors 2016)
Journal Title: International Journal of Recent Scientific Research - Year 2019, Vol 10, Issue 6
Abstract
As per WHO CNS classification 2016, grade II diffuse astrocytomas and grade III anaplastic astrocytomas are now divided into Isocitrate Dehydrogenase (IDH)-mutant, IDH-wildtype and not otherwise specified(NOS) categories. About 10 % of cases of low grade glioma that arises in young and having IDH1 mutation progress to secondary glioblastoma(GBM). So IDH sequencing is highly recommended. The study aims to show the presence of IDH1 mutation in low grade gliomas (grade II & III) and GBM and classify them as per new WHO CNS Classification 2016.Two out of five cases (40%) of anaplastic astrocytoma, nine out of fifteen cases(60%) were diffuse astrocytoma, three out of three(100%) of secondary GBM(sGBM) and none out of twenty-four of twenty-fourof primary GBM(pGBM) were IDH1 positive. Classifying grade II & III gliomas into IDH mutant and wild type categories reduces NOS Catagories. Immunohistochemistry (IHC) is a simple and valuable diagnostic tool in assessing the IDH1 mutational status.
Authors and Affiliations
PP Mishra, A Mahapatra, Kalpalata Tripathy, SK Mishra
Keywords
Related Articles
- EP ID EP645372
- DOI 10.24327/IJRSR
- Views 108
- Downloads 0
Personality and perceived stress among medical college students
Objectives: The present research was framed to investigate the relationship between personality traits (Neuroticism and Psychoticism tendencies) and perceived stress among medical college students. Methods: The sample in...
Anti-diabetic potential of herbal medicinal plants
Diabetes mellitus is probably the common metabolic disorders and a couple of. 8% with the population is suffering from this disease across the world which may well cross 5. 4% from the year 2025. Oral anti-hyperglycemic...
Systemic antibiotic therapy in the treatment of periodontitis
Periodontitis is characterized by a general inflammation of the tooth-supporting tissues, which leads to apical migration of the junctional epithelium along the root surface and progressive destruction of the periodontal...
Scores of locus of control behavior scale (lcb) and stuttering severity instrument (ssi) in individuals with stuttering - a correlation study
Background: The present study aims at investigating the response of individuals with stuttering to the locus of control behaviour scale and on severity of stuttering behavior (SSI). The specific objective is to see the c...
Placenta percreta involving the bladder: a case report
Placenta percreta in early pregnancy involving the urinary bladder is a rare condition. It is potentially a life threatening condition because of its propensity for severe haemorrhage. Antenatal diagnosis can be done wit...